Results 121 to 130 of about 6,492,501 (315)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Theory as Guide to Supervisory Practice: A Hermeneutics of Imitation and Reflection in Dialogue

open access: yes, 2016
In this paper I have employed several theoretical and theological perspectives to reflect upon my supervision of pastoral counseling.These perspectives have been applied to two pastoral supervision cases to explore a number of dynamic themes that recur ...
Franzen, David M.
core  

Place-Based Education Is an Intergenerational Practice [PDF]

open access: yes, 2011
This article makes theoretical links between place-based education and intergenerational learning supported by an analysis of data from an empirical study. The paper argues that school-linked place-based education does more than provide opportunities for
Mannion, Greg, Adey, Claire
core  

Practice Research Partnerships in Social Work:Addressing Impact and Credible Evidence [PDF]

open access: yes
Purpose: This article builds on the Practice Research Collaboratives (PRCs) as an initiative that developed from the Fifth Conference on Practice Research to provide a platform for practice researchers to engage actively around impact and influence ...
Fouché, Christa   +6 more
core   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

open access: yesFEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia   +6 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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