Results 151 to 160 of about 66,648 (290)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Facilitation on the run: Enabling work-based facilitation in the midst of practice [PDF]

, 2017
The vision of person-centred cultures is core to all policy and standards in healthcare in Ireland (Health Information and Quality Authority, 2012) and globally (World Health Organisation, 2016) implementing these strategies and standards require focused
Hardiman, Michele
core  

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Current experience and future potential of facilitating access to digital NHS primary care services in England: the Di-Facto mixed-methods study

Health and Social Care Delivery Research
Background Current National Health Service policy in England encourages enhanced digital access in primary care service provision. In this study, we investigate ‘digital facilitation’ – that range of processes, procedures and personnel which seeks to ...
Gary Abel, Helen Atherton, Jon Sussex, Nurunnahar Akter, Abodunrin Q Aminu, Wiktoria Bak, Carol Bryce, Christopher E Clark, Emma Cockcroft, Hamish Evans, Evangelos Gkousis, Georgia Jenkins, Caroline Jenkinson, Nada Khan, Jeffrey Lambert, Brandi Leach, Christine Marriott, Jennifer Newbould, Sarah Parkinson, Jo Parsons, Emma Pitchforth, Laura Sheard, Stephanie Stockwell, Chloe Thomas, Bethan Treadgold, Rachel Winder, John L Campbell   +26 more
doaj   +1 more source

Is more better? The impact of implementing more interventions for hypertension control in a practice facilitation study for small- and medium-sized practices. [PDF]

J Hum Hypertens, 2023
Ross SM, Wang A, Anthony L, Persell SD, Yu J, Kho AN.   +5 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Practice facilitation for scale up of clinical decision support for hypertension management: study protocol for a cluster randomized control trial. [PDF]

Contemp Clin Trials, 2023
Blecker S, Gannon M, De Leon S, Shelley D, Wu WY, Tabaei B, Magno J, Pham-Singer H.   +7 more
europepmc   +1 more source

The Concept of Facilitation in the Implementation of Evidence-Based Practice: Development of an Instrument to Measure Facilitation

, 2011
In 2001 the Institute of Medicine identified a significant gap between what is known about how we care for patients and the care that they receive. This identified gap renewed interest in the development and implementation of evidence-based practice (EBP)
Brown, Susan J.
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

FROM NAPCRG: FOURTH INTERNATIONAL CONFERENCE ON PRACTICE FACILITATION. [PDF]

Ann Fam Med, 2021
Nagykaldi Z, Davis MM, Lipman PD, Dluzak L, Haddad L, ICPF Steering Committee.   +5 more
europepmc   +1 more source