Results 131 to 140 of about 66,648 (290)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Facilitation of children’s agency as dialogic education: examples from practice and reflection on practice, including a critical comparison with neo-vygotskian methodologies [PDF]

open access: yes
Based on a thorough consideration of pedagogical and sociological literature, combined with the authors’ reflection on their own pedagogical practice, this article discusses the circular relationships between facilitation of children’s agency and ...
Farini, Federico ; id_orcid   +1 more
core   +3 more sources

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Estimated prevalence of people with learning disabilities: template for general practice

open access: yes, 2008
BACKGROUND In 2001, a white paper set out a commitment to ensure that people with a learning disability receive equal access to health services, with an expectation that general practices would have identified all people with a learning disability ...
Cottrell, D.   +13 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Practice Facilitation to Support Family Physicians in Encouraging COVID-19 Vaccine Uptake: A Multimethod Process Evaluation. [PDF]

open access: yesAnn Fam Med, 2023
Shuldiner J   +20 more
europepmc   +1 more source

An exploration of developing skilled facilitation within transformational practice development in healthcare

open access: yes, 2018
University of Technology Sydney. Faculty of Health.Facilitation is key to engaging people in transformational change and facilitators require considerable skill.
Kelly, Margaret Teresa
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

GSS Facilitation

open access: yes
The objectives of this chapter are to describe the nature of reflective practice and the development of reflective practice in one human aspect of information technology application, namely, the facilitation of face-to face electronic meetings.
Brent Gallupe, Pak Yoong
core   +1 more source

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