Results 121 to 130 of about 66,648 (290)

How to use communities of practice to support change in learning health systems: A landscape of roles and guidance for management

Learning Health Systems
Background Communities of practice support evidence‐based practice and can be, in and of themselves, applied learning spaces in organizations. However, the variety of ways that communities of practice can support learning health systems are poorly ...
Stephanie P. Brooks, Esther Ekpe Adewuyi, Tracy Wasylak, Denise Thomson, Sara N. Davison, Kate Storey   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Towards an explicit modeling of trade facilitation in CGE models: evidence from Egypt

This paper develops a dynamic computable general equilibrium (CGE) model incorporating trade facilitation aspects. This paper’s contributions are twofold: theoretical and empirical.
Zaki, Chahir
core  

Improving Facilitation Through Levelising: Reflecting In and On Practice

, 2011
This study explored the experience of engaging in reflective practice through the framework of Levelising. Reflective practice has been of interest to professionals and educators of professionals for many years.
Creekmore, Willard Donald
core  

Systematic Review of Practice Facilitation and Evaluation of a Chronic Illness Care Management Tailored Outreach Facilitation Intervention for Rural Primary Care Physicians [PDF]

, 2009
Nearly two decades of research on translating evidence-based care guidelines into practice has resulted in a considerable body of primary and secondary evidence about guideline implementation strategies and the individual, organizational and ...
Baskerville, Neill
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A mixed methods evaluation of mechanisms for facilitation in pediatric primary care

Implementation Science Communications
Background Understanding how implementation strategies work is vitally important for the deployment of evidence-based practices (EPBs) in healthcare settings.
Jennifer M. Boggs, Nathaniel Williams, Claire R. Waller, Mallika Pandey, Christina Johnson, Brian K. Ahmedani, Celeste Pappas, Katy Bedjeti, Melissa Maye, Courtney Benjamin Wolk, Alison M. Buttenheim, Kristin A. Linn, Leslie Wright, Matthew F. Daley, Dylan S. Small, Rinad S. Beidas   +15 more
doaj   +1 more source

A facilitation task taxonomy for communities of practice

, 2005
The role of a facilitator is key to the effective establishment and sustainment of Communities of Practice (COP). This paper presents a taxonomy of facilitation tasks that have to be carried out to support various COP processes that take place during the
Tarmizi, Halbana, de Vreede, Gert Jan, Halbana Tarmizi, Gert-jan De Vreede   +3 more
core  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source