Results 81 to 90 of about 301,813 (312)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Prevention and treatment of pressure ulcers by newest recommendations from European Pressure Ulcer Advisory Panel (EPUAP): practical reference guide for GPs

Family Medicine & Primary Care Review, 2017
The guideline titled “Prevention and treatment of pressure ulcers: clinical practice guideline” is the result of a collaborative effort between the National Pressure Ulcer Advisory Panel (NPUAP), European Pressure Ulcer Advisory Panel (EPUAP) and Pan ...
Jakub Taradaj
doaj   +1 more source

The practicality of practice guidelines [PDF]

Canadian Medical Association Journal, 2011
Clinical practice guidelines are often underused in Canada because developers fail to address potential barriers to implementation during the development and dissemination of recommendations, knowledge transfer experts told delegates to the Canadian Clinical Practice Guideline Summit in Gatineau,
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Reporting Guidelines for Healthcare Guideline Adaptations: An Interpretation of the RIGHT-Ad@pt Checklist

Xiehe Yixue Zazhi
Clinical practice guideline adaptation (hereinafter referred to as "guideline adaptation") is the consolidation and revision of existing high-quality guidelines so that the recommendations are better suited to the specific needs of different regions ...
GONG Liyun, WANG Xiaomei, PENG Guoqing, YU Huan, TAO Xiaoman   +4 more
doaj   +1 more source

Customized clinical practice guidelines for management of adult cataract in Iran

Journal of Ophthalmic & Vision Research, 2015
Purpose: To customize clinical practice guidelines (CPGs) for cataract management in the Iranian population. Methods: First, four CPGs (American Academy of Ophthalmology 2006 and 2011, Royal College of Ophthalmologists 2010, and Canadian Ophthalmological
Zhaleh Rajavi, Mohammad Ali Javadi, Narsis Daftarian, Sare Safi, Farhad Nejat, Armin Shirvani, Hamid Ahmadieh, Saeid Shahraz, Hossein Ziaei, Hamidreza Moein, Behzad Fallahi Motlagh, Sepehr Feizi, Alireza Foroutan, Hassan Hashemi, Seyed Javad Hashemian, Mahmoud Jabbarvand, Mohammad Reza Jafarinasab, Farid Karimian, Hossein Mohammad-Rabei, Mehrdad Mohammadpour, Nader Nassiri, Mahmoodreza Panahi-Bazaz, Mohammad Reza Rohani, Mohammad Reza Sedaghat, Kourosh Sheibani   +24 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Audit of medication management of acute behavioural disturbance: exploring the impact of a clinical practice guideline

, 2007
Objective This paper describes an evaluation of the impact of a concise, portable guideline for the medication management of acute behavioural disturbance in adult psychiatric inpatient units.
Sheridan, J, Chan, G, Sue, JL, Lan, YW, Cu, E, Williams, H, Lo, RKC, Wheeler, AJ   +7 more
core   +1 more source

Comparison of the Effect of Clinical Practice Guide of Budesonide (Pulmicort) and Standard Method in the Management of Asthma Attack

مجله دانشکده پزشکی اصفهان, 2019
Background: Asthma is the most common chronic respiratory tract disorder, and so far, numerous methods for controlling asthma attacks have been presented.
Elham Shahbazi-Dastjerdeh, Babak Masoumi, Mehrdad Esmailian   +2 more
doaj   +1 more source