Results 131 to 140 of about 1,365,427 (315)

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Implementing evidence-based practice in primary care: perceptions of a multifaceted programme to encourage guideline use

, 2002
Objective To explore the acceptability of the various elements of a multifaceted intervention designed to facilitate the process of guideline implementation by primary care teams and to understand constraints to the use of guidelines in this setting.
Kaba, Evridiki, Mead, Paula, Tovey, Phillip, Marshall, Joyce, Jones, Karen   +4 more
core  

Development and dissemination of institutional practice guidelines on medical end-of-life decisions in Dutch health care institutions

, 2010
Objectives: To describe how Dutch healthcare institutions develop and disseminate institutional practice guidelines on medical end-of-life decisions and policy statements on euthanasia and physician-assisted suicide (EAS) to relevant parties, and to ...
Wal, G. van der, Maas, Paul, Pasman, H.R.W., van der Heide, A., Maas, P.J. van der, Hesselink, B.A.M., van der Heide, Agnes; id_orcid, Onwuteaka-Philipsen, B.D., van der Maas, P.J., van der Wal, G., Hesselink, BAM, Pasman, HRW, van der Wal, G, Onwuteaka-Philipsen, BD, Heide, A. van der   +14 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

CONDICIÓN DE SALUD Y CUMPLIMIENTO DE LA GUÍA CLÍNICA CHILENA PARA EL CUIDADO DEL PACIENTE DIABÉTICO TIPO 2 HEALTH CONDITION AND COMPLIANCE OF THE CHILEAN CLINICAL GUIDELINE FOR TYPE 2 DIABETIC PATIENTS

Ciencia y Enfermería, 2012
Objetivo: Identificar condición de salud (CS) de los pacientes diabéticos tipo 2. Medir el cumplimiento de las atenciones de salud según guía clínica. Identificar variables asociadas a CS. Material y método: estudio de pre-valencia, abril 2010. Población:
Ma Alejandra Galiano G, Ma Silvia Calvo A, Ma Alicia Feito T, Ma Waleska Aliaga B, Sara Leiva M, Beatriz Mujica P   +5 more
doaj  

A survey of the prevalence and patterns of neuropsychological assessment practices across epilepsy surgery centers in India: Toward establishing a national guideline

Epilepsia Open
Neuropsychology plays an important role in optimizing epilepsy management, but there are no practice guidelines for low‐ and middle‐income countries with emerging services.
Urvashi Shah, Chaturbhuj Rathore, Kurupath Radhakrishnan, Neeraj Baheti, Shweta Kadaba, Aparna Sahu, Suvarna Alladi, Sonal Chitnis, Annamma George, Atma Ram Bansal, Jagarlapudi M. K. Murthy, for the National Epilepsy Surgery Support Activity Network (NESSAN)   +11 more
doaj   +1 more source

Standardized Reporting of Clinical Practice Guidelines: A Proposal From the Conference on Guideline Standardization

, 2003
Despite enormous energies invested in authoring clinical practice guidelines, the quality of individual guidelines varies considerably. The Conference on Guideline Standardization (COGS) was convened in April 2002 to define a standard for guideline ...
Shiffman, Richard N., Overhage, J. Marc, Grimshaw, Jeremy, Slutsky, Jean, Shekelle, Paul, Deshpande, Aniruddha M.   +5 more
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source