Results 121 to 130 of about 1,214,653 (312)
Clinical practice guidelines: what are they and how should they be disseminated?
Hand Clinics, 2014 Clinical practice guidelines summarize the available evidence for patient management in a format that is easy for clinicians to use. These guidelines usually use methodologically rigorous principles for retrieving and evaluating the literature and for ...
B. Graham
semanticscholar +1 more source
Environmental Education should go further [PDF]
, 2000 Outlines Scottish national policy guidelines on 'education for sustainable development' (environmental education for ages 5-14) and implications for primary schools. Describes a 2-year project in which a research team helped staff at an elementary school
Laing, Moira, McNaughton, Marie Jeanne
core
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Toward a document evaluation methodology: What does research tell us about the validity and reliability of evaluation methods? [PDF]
, 2000 Although the usefulness of evaluating documents has become generally accepted among communication professionals, the supporting research that puts evaluation practices empirically to the test is only beginning to emerge. This article presents an overview
Jong, Menno de, Schellens, Peter Jan
core +4 more sources
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source
Nursing OpenAim To compare knowledge of Nursing Degree students about Best Practice Guidelines when there are included as teaching content in a subject vs knowledge through having the usual internship experience without teaching specific guidelines contents.
Rosa García‐Sierra +4 more
doaj +1 more source
Brazilian Journal of Otorhinolaryngology, 2011 Benign Paroxysmal Positional Vertigo (BPPV) is characterized by vertigo, lasting for a few seconds and usually managed by head positioning maneuvers. To educate clinicians concerning the state-of-the art knowledge about its management, the international ...
André Luís dos Santos Silva +5 more
doaj +1 more source
JAMA Network OpenImportance Traditional approaches to practice guidelines frequently result in dissociation between strength of recommendation and quality of evidence. Objective To create a clinical guideline for the diagnosis and management of urinary tract infections
Z. Nelson +53 more
semanticscholar +1 more source