Results 51 to 60 of about 1,627,553 (249)

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Participation and consultation engagement strategies have complementary roles: A case study of patient and public involvement in clinical practice guideline development

Health Expectations, 2020
Background Patient and public involvement (PPI) is recommended when developing high‐quality clinical practice guidelines, but the effects of different PPI strategies are largely unstudied.
Melissa J. Armstrong, Gary S. Gronseth, Anna R. Gagliardi, C. Daniel Mullins   +3 more
doaj   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

Defining ‘elderly’ in clinical practice guidelines for pharmacotherapy

Pharmacy Practice, 2014
Objective: To identify how ‘elderly’ patients are defined and considered within Australian clinical guidelines for the use of pharmacotherapy. Method: Guidelines pertaining to the use of pharmacotherapy, focusing on conditions described in National ...
Singh S, Bajorek B
doaj  

Diagnostic and therapeutic guidelines for plaque psoriasis - Brazilian Society of Dermatology

Anais Brasileiros de Dermatologia
: Psoriasis is a chronic inflammatory disease that affects 1.3% of the Brazilian population. The most common clinical manifestations are erythematous, scaling lesions that affect both genders and can occur on any anatomical site, preferentially ...
Marcelo Arnone, Maria Denise Fonseca Takahashi, André Vicente Esteves de Carvalho, Wanderley Marques Bernardo, Aline Lopes Bressan, Andrea Machado Coelho Ramos, Aripuanã Cobério Terena, Cacilda da Silva Souza, Daniel Holthausen Nunes, Maria Cecília de Carvalho Bortoletto, Maria de Fátima Santos Paim de Oliveira, Jane Marcy Neffá, Luciana Cristina Fieri, Luna Azulay-Abulafia, Paulo Antônio Oldani Felix, Renata Ferreira Magalhaes, Ricardo Romiti, Tatiana Jerez Jaime   +17 more
doaj   +1 more source

Sperm DNA Fragmentation: A Critical Assessment of Clinical Practice Guidelines

The World Journal of Men's Health, 2022
Sperm DNA fragmentation (SDF) is implicated in male infertility and adverse reproductive outcomes. With the publication of many studies regarding the etiologies and contributors to SDF, as well as the effects of SDF, guidelines are necessary to aid ...
Ashok Agarwal, Ala’a Farkouh, Neel Parekh, Armand Zini, Mohamed Arafa, Hussein Kandil, Nick Tadros, Gian Maria Busetto, Rafael Ambar, Sijo Parekattil, Florence Boitrelle, Hassan Sallam, Sunil Jindal, Edmund Ko, Mara Simopoulou, Hyun Jun Park, Mohammad Ali Sadighi, Ramadan Saleh, Jonathan Ramsay, Marlon Martine, Haitham Elbardisi, Juan Alvarez, Giovanni Colpi, Jaime Gosalvez, Donald Evenson, Rupin Shah   +25 more
doaj   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

Impact of using a local protocol in preoperative testing: blind randomized clinical trial.

Revista do Colégio Brasileiro de Cirurgiões
Objective: to evaluate the impact of the use of a local protocol of preoperative test requests in reducing the number of exams requested and in the occurrence of changes in surgical anesthetic management and perioperative complications.
MÔNICA LOUREIRO SANTOS, ANTÔNIO CARLOS IGLESIAS   +1 more
doaj   +1 more source

Diretrizes para detecção precoce do câncer de mama no Brasil. II - Novas recomendações nacionais, principais evidências e controvérsias

Cadernos de Saúde Pública, 2018
Resumo: O câncer de mama é a principal causa de morte por câncer em mulheres no Brasil. As novas diretrizes para detecção precoce no Brasil foram elaboradas com base em revisões sistemáticas da literatura sobre riscos e possíveis benefícios de diversas ...
Arn Migowski, Gulnar Azevedo e Silva, Maria Beatriz Kneipp Dias, Maria Del Pilar Estevez Diz, Denise Rangel Sant’Ana, Paulo Nadanovsky   +5 more
doaj   +1 more source