Results 61 to 70 of about 302,059 (306)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Development of a research agenda for general practice based on knowledge gaps identified in Dutch guidelines and input from 48 stakeholders [PDF]

, 2019
Background: Several funding organizations using different agendas support research in general practice. Topic selection and prioritization are often not coordinated, which may lead to duplication and research waste.
van Balen, Jacintha A. M., Femke P. Hohmann, Mulder, Jan Willem A., Rutten, Guy, J. André Knottnerus, Guy Rutten, Jako S. Burgers, Burgers, Jako S., van der Wouden, Johannes C., Knottnerus, J. André, Ligthart, Suzanne A., Jolanda Wittenberg, Mulder, Jan-Willem A., Hohmann, Femke P., Jacintha A. M. van Balen, Leereveld, Dieuwke, Jan-Willem A. Mulder, Wittenberg, Jolanda, van Balen, Jacintha A.M., Keuken, Debby G., Frans Dekker, Johannes C. van der Wouden, Dekker, Frans, Debby G. Keuken, Suzanne A. Ligthart, Dieuwke Leereveld   +25 more
core   +1 more source

Multidisciplinary team approach in amputated patients care: contextualising hospital services and protocols

Cadernos Brasileiros de Terapia Ocupacional, 2018
Introduction: The Brazilian Guidelines for Attention to the Health of the Amputee brings protocols of pre-surgical assistance until post prosthetic fitting rehabilitation.
Bárbara Kons dos Santos, Soraia Cristina Tonon da Luz, Kadine Bender dos Santos, Gesilani Júlia da Silva Honório, Gelcemar de Oliveira Farias   +4 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

「慢性活動性EBウイルス感染症とその類縁疾患診療ガイドライン」の文献検索を担当して [PDF]

, 2017
This report presents examples and insights obtained through the activities of JMLA Expert Searching Working Group for Clinical Practice Guidelines. The literature search team for systematic reviews of CPG-EBV consisted of 1 leader and 2 searchers.
石原, 千尋, 金田, 佳子, 小嶋, 智美, KANEDA, Yoshiko, KOJIMA, Satomi, ISHIHARA, Chihiro   +5 more
core  

Practitioner Feedback on Lung Cancer Practice Guidelines in Ontario [PDF]

, 2006
Purpose:Practitioner feedback (PF) surveys are sent to practitioners who care for lung cancer patients as each new practice guideline is completed. In this study, the PF was reviewed to assess the frequency of response to the surveys, the respondents ...
David Cameron, Mellissa Brouwers, William K. Evans, Evans, William K., Graham, Ian D., Mackay, Jean A., Jean A. Mackay, Ian D. Graham, Cameron, David, Brouwers, Mellissa   +9 more
core   +1 more source

Adapting Clinical Guidelines for the Digital Age [PDF]

Clinical guidelines are systematically developed statements to assist practitioners and patients make decisions about health care based on the latest evidence. The long, narrative format of guidelines can make adherence difficult.

core   +3 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Designing tailored maintenance strategies for systematic reviews and clinical practice guidelines using the Portfolio Maintenance by Test-Treatment (POMBYTT) framework

BMC Medical Research Methodology
Background Organizations face diverse contexts and requirements when updating and maintaining their portfolio, or pool, of systematic reviews or clinical practice guidelines they need to manage.
Michiel S. Oerbekke, Roy G. Elbers, Maarten J. van der Laan, Lotty Hooft   +3 more
doaj   +1 more source

A Position Paper on Lipoprotein(a) From the Lipoprotein(a) Task Force of the Korean Society of Lipid and Atherosclerosis: Current Evidence, Clinical Applications, and Future Directions

Journal of Lipid and Atherosclerosis
Lipoprotein(a) [Lp(a)] is a genetically determined risk factor for atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valve stenosis (CAVS), with plasma levels largely unaffected by lifestyle modification or conventional lipid-lowering ...
Youngwoo Jang, Jang Hoon Lee, Sang-Guk Lee, Hun Jee Choe, Sang Min Park, In-Kyung Jeong, Byung Jin Kim, on behalf of the Lipoprotein(a) Task Force of the Korea Society of Lipid and Atherosclerosis   +7 more
doaj   +1 more source