Results 61 to 70 of about 294,906 (262)

Prescription Writing — Best Practices to Reduce Prescribing Errors

MedEdPORTAL, 2014
Prescribing is a fundamental part of the work of new residents, who write and review many prescriptions each day. It is a complex task requiring knowledge of medicines and the diseases they are used to treat, careful judgment of risks and benefits of ...
Senthil Rajasekaran, Levi Hall, Nelia Afonso   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies [PDF]

Jornal Brasileiro de Pneumologia
Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications.
Juliana Carvalho Ferreira, Arthur Oswaldo de Abreu Vianna, Bruno Valle Pinheiro, Israel Silva Maia, Sérgio Vasconcellos Baldisserotto, Alexandre Marini Isola   +5 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1643-1660, June 2026.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Identifying and integrating consumer-prioritised topics and outcomes in clinical practice guidelines on managing kidney stones

BMC Nephrology
The prevention and management of recurrent kidney stones can be challenging and requires patients to modify their diet and daily rountines that impact their quality of life. Our study aims to describe the process of integrating consumer-prioritised topics and outcomes in guidelines on kidney stones to ensure patient relevance.Two workshops were ...
Tunnicliffe, David J., Wickham, Ieuan, Jauré, Allison, Johnston, Brydee, Mallett, Andrew J., Mullan, Adam, Lloyd, Lyn, Scholes-Roberston, Nicole, Hassan, Hicham Cheikh, Jose, Matthew   +9 more
  +7 more sources

Current approach for the prosthesis patient mismatch

Türk Kardiyoloji Derneği Arşivi, 2013
All prosthetic valves are at least mildly stenotic and have relatively high transvalvular pressure gradients that can be observed despite normal prosthesis function.
Asuman Biçer Yeşilay, Zekeriya Kaya, Recep Demirbağ   +2 more
doaj   +1 more source

Setting priorities and selecting topics for clinical practice guidelines.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1996
Setting priorities and selecting topics are important steps in guidelines development, but they have received relatively little attention to date. Responses from a survey of guidelines stakeholders in Canada suggest that the health burden of a clinical condition on the population is an important factor in priority setting. Economic considerations, cast
R N, Battista, M J, Hodge
openaire   +1 more source

Development of clinical practice guidelines for supportive care in childhood cancer—prioritization of topics using a Delphi approach

Supportive Care in Cancer, 2014
Currently, very few guidelines for supportive care for children with cancer exist. In the Netherlands, nationwide guidelines are over 10 years old and mostly based on expert opinion. Consequently, there is growing support and need for clinical practice guidelines (CPGs), which ought to be developed with a well-defined methodology and include a ...
Loeffen, E. A. H., Mulder, R. L., Kremer, L. C. M., Michiels, E. M. C., Abbink, F. C. H., Ball, L. M., Segers, H., Mavinkurve-Groothuis, A. M. C., Smit, F. J., Vonk, I. J. M., Vd Wetering, M. D., Tissing, W. J. E., van der Wetering, M.   +12 more
openaire   +4 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source