Results 81 to 90 of about 302,059 (306)

Chlamydia screening in general practice: views of professionals on the key elements of a successful programme. [PDF]

, 2005
OBJECTIVES: Chlamydia trachomatis is a common sexually transmitted infection with serious consequences if not treated. Chlamydia screening pilots in England have established feasibility in primary care but there are currently no examples of good practice
R. Ma, A. Clark, Ma, Richard, Clarke, Aileen   +3 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Adapting Clinical Guidelines for the Digital Age Meeting [PDF]

AGENCY: Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS).ACTION: Notice of meeting.SUMMARY: The Centers for Disease Control and Prevention (CDC) announces the Adapting Clinical Guidelines for the Digital Age

core  

Identifying and integrating consumer-prioritised topics and outcomes in clinical practice guidelines on managing kidney stones

BMC Nephrology
The prevention and management of recurrent kidney stones can be challenging and requires patients to modify their diet and daily rountines that impact their quality of life. Our study aims to describe the process of integrating consumer-prioritised topics and outcomes in guidelines on kidney stones to ensure patient relevance.Two workshops were ...
Tunnicliffe, David J., Wickham, Ieuan, Jauré, Allison, Johnston, Brydee, Mallett, Andrew J., Mullan, Adam, Lloyd, Lyn, Scholes-Roberston, Nicole, Hassan, Hicham Cheikh, Jose, Matthew   +9 more
  +7 more sources

Setting priorities and selecting topics for clinical practice guidelines.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1996
Setting priorities and selecting topics are important steps in guidelines development, but they have received relatively little attention to date. Responses from a survey of guidelines stakeholders in Canada suggest that the health burden of a clinical condition on the population is an important factor in priority setting. Economic considerations, cast
R N, Battista, M J, Hodge
openaire   +1 more source

Development of clinical practice guidelines for supportive care in childhood cancer—prioritization of topics using a Delphi approach

Supportive Care in Cancer, 2014
Currently, very few guidelines for supportive care for children with cancer exist. In the Netherlands, nationwide guidelines are over 10 years old and mostly based on expert opinion. Consequently, there is growing support and need for clinical practice guidelines (CPGs), which ought to be developed with a well-defined methodology and include a ...
Loeffen, E. A. H., Mulder, R. L., Kremer, L. C. M., Michiels, E. M. C., Abbink, F. C. H., Ball, L. M., Segers, H., Mavinkurve-Groothuis, A. M. C., Smit, F. J., Vonk, I. J. M., Vd Wetering, M. D., Tissing, W. J. E., van der Wetering, M.   +12 more
openaire   +4 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Towards Computable Guidelines and Beyond with FHIR [PDF]

Maria-Michaels-Towards-Computable-Guidelines-and-Beyond-with-FHIR-DevDays-2019-Redmond ...

core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Appraisal of physical health guidelines for severe mental illness [PDF]

, 2020
Objectives: The aim of this study was to identify current physical health guidelines for severe mental illness (SMI) and appraise them using the Appraisal of Guidelines for Research and Evaluation (AGREE) II Instrument.
Siskind, D, Kisely, S, Kumar, R, Friend, N, Hughes, J   +4 more
core   +1 more source