Results 91 to 100 of about 58,209,289 (310)

Principles of prescribing and guidelines for use of topical steroids in dermatology practice

Journal of Pakistan Association of Dermatologists, 2016
Corticosteroids have been proven invaluable topical agents in treating a variety ofinflammatory conditions affecting skin. They are to be used with caution in any patient inorder to avoid untoward effects, which can be mild and respond readily to discontinuation ofthe corticosteroid agent, or be severe and even life-threatening in their impact.
openaire   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

UK ambulance services clinical practice guidelines 2013 : pocket book

, 2013
The 2013 Clinical Practice Guidelines provide guidance for NHS paramedics; although the principles are applicable to the work of all pre-hospital clinicians.
Joint Royal Colleges Ambulance Liaison Committee,, National Health Service,, Association of Ambulance Chief Executives,, University of Warwick,   +3 more
core  

Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies [PDF]

Jornal Brasileiro de Pneumologia
Mechanical ventilation can be a life-saving intervention, but its implementation requires a multidisciplinary approach, with an understanding of its indications and contraindications due to the potential for complications.
Juliana Carvalho Ferreira, Arthur Oswaldo de Abreu Vianna, Bruno Valle Pinheiro, Israel Silva Maia, Sérgio Vasconcellos Baldisserotto, Alexandre Marini Isola   +5 more
doaj   +1 more source

Development of clinical practice guidelines for supportive care in childhood cancer—prioritization of topics using a Delphi approach

Supportive Care in Cancer, 2014
Currently, very few guidelines for supportive care for children with cancer exist. In the Netherlands, nationwide guidelines are over 10 years old and mostly based on expert opinion. Consequently, there is growing support and need for clinical practice guidelines (CPGs), which ought to be developed with a well-defined methodology and include a ...
Loeffen, E. A. H., Mulder, R. L., Kremer, L. C. M., Michiels, E. M. C., Abbink, F. C. H., Ball, L. M., Segers, H., Mavinkurve-Groothuis, A. M. C., Smit, F. J., Vonk, I. J. M., Vd Wetering, M. D., Tissing, W. J. E., van der Wetering, M.   +12 more
openaire   +4 more sources

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

PP61 Equity As A Criterion For Prioritizing Topics For The Development Of Clinical Practice Guidelines

International Journal of Technology Assessment in Health Care
Introduction Equity is a pivotal element in health technology assessment (HTA) to ensure fair and proportional access to healthcare needs and to mitigate health disparities. The incorporation of equity-oriented prioritization criteria into the development of clinical practice guidelines (CPGs) promotes social ...
Pereira, Maíra, Simone, Adriane Lopes Medeiros, Saldanha, Tainá, Rodrigues, Mônica, Martins, Tamiê, Melo, Daniela   +5 more
openaire   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

ESC Guidelines—Contributing to Quality in Clinical Practice

, 2015
The European Society of Cardiology (ESC) has dedicated itself to the publication and dissemination of clinical practice guidelines. This is regarded one of the core products generated within the ESC, and is intended to reflect updated, topic-related ...
Dan Atar
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source