Results 31 to 40 of about 1,131,757 (261)

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source

Analysis of the current status, challenges, and strategies of continuing professional development for graduates of rural bonded general practitioner education program in Guizhou province

Chinese General Practice Journal
Background: The competency of graduates of rural bonded general practice education program has attracted widespread attention. Strengthening continuing professional development is an important measure to enhance the competency of general practitioners ...
Haifeng Pu, Yinsheng Wang, Lingli Chen, Xue Xiao, Nian Zhang, Chuying Chen, Jiming Zhu, Changyin Yu   +7 more
doaj   +1 more source

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait, R. Al‐Saadi, A. Lopez‐Cortes, K. Dzhuma, M. Oostveen, J. Brok, S. Irtan, M. Weeks, J. Bate, S. Baker, R. Williams, M. Powis, D. Saunders, O. Olsen, T. Watson, S. Shelmerdine, S. Vaidya, L. Howell, C. Duncan, G. M. Vujanic, C. Stiller, G. P. Balchin, T. Chowdhury, K. Pritchard‐Jones   +23 more
wiley   +1 more source

Development of a risk assessment model for multimorbidity of diabetes, hypertension, and coronary heart disease with XGBoost in primary care in Shanghai, China: a retrospective study

BMC Cardiovascular Disorders
Background Multimorbidity has emerged as a growing global health concern. Within its heterogeneous patterns, the cardiometabolic cluster is notably among the most common.
Ning Chen, Peipei Zhang, Feng Fan, Hua Jin, Yanying Chen, Jing Liu, Lin Chen, Xiaoguang Wan, Jing Guo, Zaijia Yang, Lei Sun, Houqian Shan, Dehua Yu, Zhaoxin Wang, Jianwei Shi   +14 more
doaj   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

The integral role of lifestyle in the prevention and management of hypertension and associated cardiometabolic and cognitive disorders: a review

Frontiers in Endocrinology
Hypertension represents a paramount global health challenge, intricately linked to cardiovascular, metabolic, and cognitive morbidity. This narrative review provides a critical synthesis of current evidence, anchored by a systematic literature search, to
Qian Wang, Dan Wu, Yan Huang, Yan Huang, Yan Huang, Yan Huang   +5 more
doaj   +1 more source

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski, Rebecca Ronsley, Shannon M. Stasi, Jeffrey Stevens, Erin R. Rudzinski, Christina M. Lockwood, Sarah E. S. Leary, Bonnie L. Cole, Michelle A. Ting, Vera Paulson   +9 more
wiley   +1 more source

Core reference ontology for individualized exercise prescription

Scientific Data
“Exercise is medicine” emphasizes personalized prescriptions for better efficacy. Current guidelines need more support for personalized prescriptions, posing scientific challenges.
Xingyun Liu, Yin Yang, Hui Zong, Ke Zhang, Min Jiang, Chunjiang Yu, Yalan Chen, Ting Bao, Danting Li, Jiao Wang, Tong Tang, Shumin Ren, Juan M. Ruso, Bairong Shen   +13 more
doaj   +1 more source

Preferences of Pediatric Patients and Their Caregivers for Chemotherapy‐Induced Nausea and Vomiting Control Endpoints: A Mixed Methods Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Although not always achieved, complete chemotherapy‐induced nausea and vomiting (CINV) control is the conventional goal of CINV prophylaxis. In this two‐center, mixed‐methods study, we sought to understand the preferences of adolescent patients and family caregivers for CINV control endpoints.
Haley Newman, Tadi Hondonga, Alison Berry, Caitlin Elgarten, Jason Freedman, Katelyn Oranges, Sara McDonough, Caroline Diorio, L. Lee Dupuis   +8 more
wiley   +1 more source

Protocolled practice nurse-led care for children with asthma in primary care: protocol for a cluster randomised trial

BMJ Open, 2019
Introduction In children with asthma, daily symptoms and exacerbations have a significant impact on the quality of life of both children and parents. More effective use of asthma medication and, consequently, better asthma control is advocated, since ...
Patrick J E Bindels, Arthur M Bohnen, Sara Bousema, Annemieke J Verwoerd, Lucas M Goossens, Gijs Elshout   +5 more
doaj   +1 more source