Results 51 to 60 of about 1,170,202 (262)

The Impact of Home Medication Management Practices on Medication Adherence

Behavioral Sciences
Medication adherence is a vexing challenge with nonadherence at 50% or greater among US adults. With most medications self-administered by patients in the home, home medication management practices, especially where patients store medication in the home and receptivity to guidance from healthcare providers, need to be better understood to improve ...
Lisa Gualtieri, Meredith Steinfeldt, Eden Shaveet, Brandon Estime, Meera Singhal   +4 more
openaire   +3 more sources

Practical Approach of Knowledge Management in Medical Science

CoRR, 2020
Knowledge organization, infrastructure, and knowledge-based activities are all subjects that help in the creation of business strategies for the new enterprise. In this paper, the first basics of knowledge-based systems are studied. Practical issues and challenges of Knowledge Management (KM) implementations are then illustrated.
Mahdi Bohlouli, Patrick Uhr, Fabian Merges, Sanaz Mohammad Hassani, Madjid Fathi   +4 more
openaire   +2 more sources

U-shaped association between TC/HDL-C ratio and the risk of metabolic dysfunction-associated fatty liver disease in older adults

European Journal of Medical Research
This cross-sectional study aimed to evaluate the association between the total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and metabolic dysfunction-associated fatty liver disease (MAFLD) risk in older adults. Utilizing data from
Jie Zhou, Jian Dong, Wenyan Zhao, Min Zhao   +3 more
doaj   +1 more source

Complementary, alternative, and integrative medicine therapies for knee osteoarthritis: a visual analytics analysis of the research domain

Frontiers in Medicine
IntroductionKnee osteoarthritis (KOA) affects 528 million people globally, with prevalence projected to rise by 74.9% by 2050. Traditional treatments face limitations in long-term safety and efficacy, driving interest in complementary, alternative, and ...
Chuqing Luo, Chuqing Luo, Jing Wang, Jing Wang, Jiaojiao Guo, Jiaojiao Guo   +5 more
doaj   +1 more source

Discontinuation of the PACE Plus trial: problems in patient recruitment in general practice

BMC Musculoskeletal Disorders, 2018
Background The PACE Plus trial was a multi-center, double-blinded, superiority randomized controlled trial (RCT) conducted in patients from Dutch general practice to investigate the efficacy of paracetamol and NSAIDs in acute non-specific low back pain ...
M. Schreijenberg, P. A. J. Luijsterburg, Y. D. M. Van Trier, D. Rizopoulos, M. A. Koopmanschap, L. Voogt, C. G. Maher, B. W. Koes   +7 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A multicenter cross-sectional study on perceptions and peer-reported prevalence of research misconduct among Chinese medical postgraduates

Scientific Reports
This study aimed to explore the gap between attitudes towards and personally observed breaches of research integrity among medical postgraduates in China, a critical yet understudied population.
Tang Haitao, Zhou Jingya, Wang Jinsong, Zeng Wen   +3 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source