Results 51 to 60 of about 3,737,851 (258)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Knowing Your Population: Privacy-Sensitive Mining of Massive Data
, 2013 Location and mobility patterns of individuals are important to environmental planning, societal resilience, public health, and a host of commercial applications.
Boman, Magnus +4 more
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Software Development Practices Patterns [PDF]
, 2017 Nuestro objetivo final es proponer un catálogo con recomendaciones sobre cómo organizar el trabajo de los programadores. En esta investigación pretendemos proporcionar experimentos para explorar las formas más adecuadas para permitir a los programadores desarrollar software, ya sea solo, en programación en pareja o en grupo.
Herez Moise Kattan, Alfredo Goldman
openaire +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Physician Dual Practice: Access Enhancement or Demand Inducement? [PDF]
In many developing countries, the majority of physicians employed in government clinics also have a private practice. We develop a simple model to show that allowing dual practice helps low-income governments retain skilled physicians to assure patient ...
Anupa Bir, Karen Eggleston
core
New design approaches to repurposing open educational resources for collaborative learning using mediating artefacts [PDF]
, 2009 In spite of high expectations and the support given by prestigious funding and educational institutions, Open Educational Resources (OER) have not been adopted widely by teachers and learners in practice.
Conole, Grainne +3 more
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Transverse rotation and longitudinal translation during prosthetic gait - a literature review [PDF]
, 2003 Improved technology allows for more accurate gait analysis to increase awareness of nonoptimized prosthetic gait patterns and for the manufacture of sophisticated prosthetic components to improve nonoptimized gait patterns. However, prescriptions are
Rithalia, S, Twiste, M
core