Results 1 to 10 of about 19,032 (124)

Prepectoral no mesh versus mesh immediate implant-based reconstruction after mastectomy (Restore-B): a multicentre single-blinded randomised controlled feasibility study protocol [PDF]

BMJ Open
Introduction Breast cancer is common and women requiring mastectomy will be offered a breast reconstruction if they are surgically suitable candidate. Breast reconstruction can be performed at the same time as the mastectomy (immediate) or delayed to a ...
, Sue Ziebland, Amy Taylor, Pankaj Roy, Rachel Rolph, Joanna Wakefield-Scurr, Michael Douek, Marcelle Bernstein, Sarah Markham, Avi Agrawal, Jonathan Alistair Cook, Dibendu Betal, Richard Rainsbury, Cynthia Iglesias, Suzy Cleator, Brendan Smith, Charles Malyon, Jessica Scaife, Aimee Hennessy, Jennifer Rusby, Riccardo Bonomi, Edward St-John, Timothy Martyn Hill, Mark HoAsjoe, Jack Elkes   +24 more
doaj   +2 more sources

Avoiding Routine Oxygen Therapy in Patients With Myocardial Infarction Saves Significant Expenditure for the Health Care System—Insights From the Randomized DETO2X-AMI Trial

Frontiers in Public Health, 2022
Background: Myocardial infarction (MI) occurs frequently and requires considerable health care resources. It is important to ensure that the treatments which are provided are both clinically effective and economically justifiable.
Robin Hofmann, Tamrat Befekadu Abebe, Johan Herlitz, Stefan K. James, Stefan K. James, David Erlinge, Joakim Alfredsson, Joakim Alfredsson, Tomas Jernberg, Thomas Kellerth, Annica Ravn-Fischer, Annica Ravn-Fischer, Bertil Lindahl, Bertil Lindahl, Sophie Langenskiöld, DETO2X-SWEDEHEART Investigators   +15 more
doaj   +1 more source

The Effects of a Mindfulness Program on Mental Health in Students at an Undergraduate Program for Teacher Education: A Randomized Controlled Trial in Real-Life

Frontiers in Psychology, 2021
Background: In this study, we aimed to investigate the effects of a mindfulness program including Mindfulness-Based Stress Reduction (MBSR) on the mental health of student teachers when offered at their educational institution in a real-life context ...
Lise Juul, Eva Brorsen, Katinka Gøtzsche, Birgitte Lund Nielsen, Lone Overby Fjorback   +4 more
doaj   +1 more source

Meta-research on pragmatism of randomized trials: rationale and design of the PragMeta database

Trials, 2023
Background Pragmatic trials provide decision-oriented, real-world evidence that is highly applicable and generalizable. The interest in real-world evidence is fueled by the assumption that effects in the “real-world” are different to effects obtained ...
Julian Hirt, Perrine Janiaud, Pascal Düblin, Lars G. Hemkens   +3 more
doaj   +1 more source

Stress-free Everyday LiFe for Children and Adolescents REsearch (SELFCARE): a protocol for a cluster randomised trial testing a school teacher training programme to teach mindfulness (“.b”)

BMC Psychology, 2021
Background There is a call for sustainable, evidence-based interventions in schools to promote mental health in schoolchildren. Our primary aim of this trial is to evaluate the effectiveness in vulnerable pupils of a school teacher training programme to ...
Lise Juul, Morten Frydenberg, Michelle Sand Beck, Lone Overby Fjorback   +3 more
doaj   +1 more source

Best-BRA (Is subpectoral or prepectoral implant placement best in immediate breast reconstruction?): a protocol for a pilot randomised controlled trial of subpectoral versus prepectoral immediate implant-based breast reconstruction in women following mastectomy

BMJ Open, 2021
Background Implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure following mastectomy. IBBR techniques are evolving rapidly, with mesh-assisted subpectoral reconstruction becoming the standard of care and more
Kirsty Roberts, Clare Clement, Jodi Taylor, Chris Metcalfe, William Hollingworth, Shelley Potter, Athene Lane, Joanna Skillman, Steven Thrush, Lisa Whisker, Nicola Mills, Katherine Fairhurst, Patricia Fairbrother, Chris Holcombe, Ramsey Cutress   +14 more
doaj   +1 more source

Mesh inlay, mesh kit or native tissue repair for women having repeat anterior or posterior prolapse surgery: randomised controlled trial (PROSPECT) [PDF]

, 2020
Funding The project was funded by the National Institute for Health Research Health Technology Assessment Programme (Project Number 07/60/18). The Health Services Research Unit and the Health Economics Research Unit are funded by the Chief Scientist ...
Boyers, D, Breeman, S, Cooper, K G, Elders, A, Freeman, R M, Glazener, CMA, Hagen, S, Hemming, C, Kilonzo, M, MacLennan, G, McDonald, A, McPherson, G, Montgomery, I, Norrie, J, PROSPECT study group, Reid, F M, Smith, ARB   +16 more
core   +4 more sources

A pilot randomised trial comparing a mindfulness-based stress reduction course, a locally-developed stress reduction intervention and a waiting list control group in a real-life municipal health care setting

BMC Public Health, 2020
Background The purpose of the present study was to conduct a pilot randomised controlled trial (RCT) to lend support to a larger effectiveness RCT comparing Mindfulness-Based Stress Reduction (MBSR), a locally-developed stress reduction intervention (LSR)
Lise Juul, Karen Johanne Pallesen, Mette Bjerggaard, Corina Nielsen, Lone Overby Fjorback   +4 more
doaj   +1 more source

The iBRA (implant breast reconstruction evaluation) study: protocol for a prospective multi-centre cohort study to inform the feasibility, design and conduct of a pragmatic randomised clinical trial comparing new techniques of implant-based breast reconstruction. [PDF]

, 2016
BACKGROUND: Implant-based breast reconstruction (IBBR) is the most commonly performed reconstructive procedure in the UK. The introduction of techniques to augment the subpectoral pocket has revolutionised the procedure, but there is a lack of high ...
Barnes, NL, Blazeby, JM, Branford, OA, Breast Reconstruction Research Collaborative, Conroy, EJ, Cutress, RI, Gardiner, MD, Holcombe, C, Jain, A, McEvoy, K, Mills, N, Mylvaganam, S, Potter, S, Skillman, JM, Teasdale, EM, Thrush, S, Whisker, LJ, Williamson, PR   +17 more
core   +5 more sources

Challenges in evaluating surgical innovation [PDF]

, 2009
Research on surgical interventions is associated with several methodological and practical challenges of which few, if any, apply only to surgery. However, surgical evaluation is especially demanding because many of these challenges coincide.
Blazeby, Jane M, Boutron, Isabelle, Clavein, Pierre-Alain, Cook, Jonathan Alistair, Ergina, Patrick L, Reeves, Barnaby C, Seiler, Christoph M   +6 more
core   +1 more source