Results 21 to 30 of about 6,694,831 (167)

A pragmatic multi-centre randomised controlled trial of fluid loading and level of dependency in high-risk surgical patients undergoing major elective surgery: trial protocol [PDF]

, 2010
Background: Patients undergoing major elective or urgent surgery are at high risk of death or significant morbidity. Measures to reduce this morbidity and mortality include pre-operative optimisation and use of higher levels of dependency care after ...
Campbell, M, Kinsella John, Grant Adrian, Cuthbertson Brian H, Cook, Jonathan Alistair, Campbell, M.K., Vale, L., Brian H Cuthbertson, Grant, A, Grant, A., Cook, J, Julie Brittenden, Cook Jonathan, Brittenden Julie, Grant, Adrian Maxwell, Campbell Marion K, Norrie John, Brittenden, Julie, Foccus Study Group, Stephen A Stott, Stott Stephen A, Kinsella, J., Cook, J., Stott, SA, Kinsella, John, John Norrie, Cuthbertson, B.H., Vale, L, Adrian Grant, Vale Luke, Brittenden, J, Study Group, F, Norrie, John David, Cuthbertson, BH, null null, Marion K Campbell, Norrie, J, Stott, S.A., Kinsella, J, Cuthbertson, Brian, Brittenden, J., Luke Vale, Norrie, J., Vale, Luke David, Campbell, Marion Kay, John Kinsella, Jonathan Cook   +46 more
core   +2 more sources

Acupuncture for irritable bowel syndrome:primary care based pragmatic randomised controlled trial [PDF]

, 2012
Background: Acupuncture is used by patients as a treatment for irritable bowel syndrome (IBS) but the evidence on effectiveness is limited. The purpose of the study was to evaluate the effectiveness of acupuncture for irritable bowel syndrome in primary ...
Bloor, Karen, Ian Watt, Kang'ombe, Arthur Ricky, Whorwell, Peter; id_orcid, Helen Cox, Tilbrook, Helen, Bland, J. Martin, Watt, Ian, Kang’ombe, Arthur Ricky, David Torgerson, Stuardi, Tracy, Arthur Ricky Kang’ombe, Whorwell, Peter, Brabyn, Sally, Bland, J Martin, Hugh MacPherson, Peter Whorwell, Torgerson, David, Man, Mei See, Karen Bloor, Man, Mei-See, Mei-See Man, MacPherson, Hugh, J Martin Bland, Cox, Helen, Helen Tilbrook, Sally Brabyn, Tracy Stuardi   +27 more
core   +2 more sources

A Randomised Controlled Trial of an Energy Efficiency Intervention for Families Living in Fuel Poverty [PDF]

, 2011
This paper discusses a pragmatic randomised controlled trial of a fuel poverty intervention undertaken in NE England over a four-year period, starting in 2000/2001.
Harrington, Barbara E., Heyman, Bob, Heyman, Anna, Bob Heyman, The National Energy Action Research, null The National Energy Action Research, Harrington, Barbara, Barbara Harrington, Anna Heyman, The National Energy Action Research Group   +9 more
core   +1 more source

Pragmatic aspects of communication and language comprehension in groups of children differentiated by teacher ratings of inattention and hyperactivity. [PDF]

, 2007
Children with attention deficit hyperactivity disorder (ADHD) experience pragmatic language deficits, but it is not known whether these difficulties are primarily associated with high levels of inattention, hyperactivity, or both.
Cain, Kate, Bignell, Simon
core   +1 more source

The challenges faced in the design, conduct and analysis of surgical randomised trials [PDF]

, 2009
Randomised evaluations of surgical interventions are rare; some interventions have been widely adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial (RCT) design has not become the default study design for the ...
Cook, Jonathan Alistair
core   +2 more sources

Internal limiting membrane peeling versus no peeling for idiopathic full-thickness macular hole: a pragmatic randomized controlled trial [PDF]

, 2011
<p>Purpose: To determine whether internal limiting membrane (ILM) peeling is effective and cost effective compared with no peeling in patients with idiopathic stage 2 or 3 full-thickness maculay hole (FTMH).</p> <p>Methods: This was ...
Cook, Jonathan, Vale, L., Vale, Luke, Noemi Lois, Ternent, L., Full-thickness Macular Hole and Internal Limiting Membrane Peeling Study (FILMS) Group, McDonald, A, Cook, J, Full-Thickness Macular Hole, McPherson, G., McPherson, Gladys, Jennifer Burr, Burr, J., McDonald, A., Lois, N., Cook, J., McDonald, Alison, John Norrie, Boachie, Charles, Vale, L, Burr, Jennifer Margaret, Alison McDonald, Lois, N, Gladys McPherson, Laura Ternent, Charles Boachie, Ternent, L, McPherson, G, Ternent, Laura, Norrie, J, Luke Vale, Norrie, J., Boachie, C., Lois, Noemi, Burr, J, Boachie, C, Norrie, John, Jonathan Cook   +37 more
core   +1 more source

Organoid Brain‐Machine‐Interface Devices for Central Nervous System Repair

Advanced Science, EarlyView.
We envision organoid brain‐machine‐interface (Organoid‐BMI) devices as new biohybrid bidirectional communication pathways to connect the human CNS and the external world for personalized CNS repair and regeneration. ABSTRACT Central nervous system (CNS) repair and regeneration suffer from tremendous clinical challenges due to current limitations in ...
Yantao Xing, Yang Yang, Zichen Hong, Chunhui Tian, Huiyu Chu, Susanne Clara Prokop, Hongwei Cai, Mingxia Gu, Jason Tchieu, Ken Mackie, Feng Guo   +10 more
wiley   +1 more source

The challenges faced in the design, conduct and analysis of surgical randomised controlled trials [PDF]

, 2009
Randomised evaluations of surgical interventions are rare; some interventions have been widely adopted without rigorous evaluation. Unlike other medical areas, the randomised controlled trial (RCT) design has not become the default study design for the
Jonathan A Cook, Cook, Jonathan Alistair, Cook, JA, Cook Jonathan A   +3 more
core   +2 more sources

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, EarlyView.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Cost-effectiveness of alternative methods of surgical repair of inguinal hernia [PDF]

, 2004
Objectives: To assess the relative cost-effectiveness of laparoscopic methods of inguinal hernia repair compared with open flat mesh and open non-mesh repair.
Aitola, P., Go, P., Bringman, S., Bay-Nielsen, M., Bittner, R., Payne, J., Vale, L., Merello, J., Castoro, C., O'Dwyer, P., Barkun, J., McCormack, K., Anderberg, B., Scott, N., Fingerhut, A., Grant, A., Kingsnorth, A., Ross, S., Beets, G., Arvidsson, D., et al.   +20 more
core   +1 more source