Results 141 to 150 of about 7,099,508 (221)

Real‐World Outcomes of Midostaurin Plus Intensive Chemotherapy in FLT3‐Mutated AML: The PETHRATIFY Study

American Journal of Hematology, Volume 101, Issue 11, Page 2812-2826, November 2026.
ABSTRACT Mutations in FLT3 are present in approximately 30% of patients with AML. The addition of midostaurin (MIDO) to intensive chemotherapy (IC) became standard of care following the RATIFY trial, but comprehensive real‐world data spanning the full adult age spectrum and including both FLT3‐ITD and FLT3‐TKD mutations remain limited.
Mónica Alejandra Romero Riquelme, Gaspar Aspas Requena, Pilar Lloret‐Madrid, Cristina Gil, Eliana Aguiar, Mar Tormo, Teresa del Bernal del Castillo, Eduardo Rodríguez Arbolí, Josefina Serrano, Joaquín Sánchez‐García, Carlos Rodríguez‐Medina, José Mário Mariz, Rosa Ayala, Joaquín Martínez‐López, María Luz Amigo, Susana Vives, Lorenzo Algarra Algarra, Raimundo García Boyero, Joana Brioso, Tamara Castaño, Juan M. Bergua Burgués, Olga Salamero, María Francisca Bass Maturana, Mercedes Colorado, María García Fortes, María José Sayas Lloris, Belén Vidriales Vicente, Carmen Chillón, Esther Pérez Santaolalla, María Dolores Madrigal, Jorge Labrador Gómez, María José García Pérez, Soledad Casado Calderón, Manuel Pérez Encinas, Amaia Balerdi Malcorra, María Solé Rodríguez, Lara María Gómez García, Pilar Herrera Puente, Olga Arce Fernández, Manuel Barrios García, Víctor Noriega, Rosa Fernández, Mamen Mateos, Carolina Lacalzada, Ágata Almela Gallego, María Carmen García Garay, Carmen Couto, José Antonio Pérez‐Simón, Eva Barragán González, Pau Montesinos   +49 more
wiley   +1 more source

Artificial intelligence in cardiology: an evidence map across subspecialties, 2014-26. [PDF]

Eur Heart J Digit Health
Kołtowski Ł, Basza M, Soliński M, Rolek B, Brandberg H, Costa F, Keser N, Marketou M, Grabowski M, Vidal-Perez R, Bruining N, Svennberg E, Dudek D, Cosyns B, Balsam P, Casado-Arroyo R, Kemps H, Volterrani M, Szymański P, Desteghe L, Christodorescu R, Opolski G, Hindricks G, Asselbergs FW.   +23 more
europepmc   +1 more source

From Biological Mechanisms to Causal Inference: Quantitative Systems Pharmacology and Causal Frameworks in Drug Development

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1255-1265, November 2026.
Digital patients and in silico clinical trials offer new opportunities to advance pharmacological research, clinical development, and regulatory decision‐making by enabling the simulation of treatment effects prior to testing in patients. Among the most promising of these opportunities is the combined use of quantitative systems pharmacology (QSP) and ...
Thomas Klabunde, Ramon Hernandez, Piet H. van der Graaf, Tommaso Andreani   +3 more
wiley   +1 more source

Glycated Hemoglobin and Prediabetes: A Systematic Review of HbA1c Thresholds for Type 2 Diabetes Prevention. [PDF]

J Clin Med
Karczewski D, Karczewski T, Olsen M.
europepmc   +1 more source

First 20 Years of Orbitrap Mass Spectrometry as the Mainstream Analytical Technique

Mass Spectrometry Reviews, Volume 45, Issue 6, Page 1064-1086, November/December 2026.
ABSTRACT This review traces the first 20 years of Orbitrap mass spectrometry as a mainstream high‑resolution and accurate‑mass (HR/AM) technology. It outlines the historical development of the Orbitrap analyzer, the evolution of major instrument families, and the key technological innovations that enabled its widespread adoption. Particular emphasis is
Alexander Makarov
wiley   +1 more source

Good clinical trial funding practices: how can public funders reduce the risk of trial failure and improve health impact? [PDF]

Trials
Hulstaert F, Harrison J, Nevens H, Stocquart N, Marynen E, Pouppez C, Neyt M, Verleye L, Vrijens F.   +8 more
europepmc   +1 more source

Estimating Individualized Survival Benefit of Consolidative Metastasis‐Directed Radiotherapy Following Chemoimmunotherapy in Nasopharyngeal Carcinoma With Exclusive Distant Metastasis

MedComm, Volume 7, Issue 11, November 2026.
This study integrates target trial emulation and causal machine learning to individualize consolidative metastasis‐directed radiotherapy (MDRT) for exclusively distant metastatic nasopharyngeal carcinoma. Using a multicenter cohort of 1083 patients, we confirmed overall MDRT efficacy via a cloning–censoring–weighting approach.
Xuguang Wang, Shuwei Chen, Xing Zhang, Linfei Mao, Jingtao Chen, Shida Yan, Jiawei Xie, Xianlu Gao, Liji Zheng, Yujie Zeng, Shiting Zhang, Zekun Deng, Mingyuan Du, Ming Song   +13 more
wiley   +1 more source

Balancing rigor and pragmatism in health research: a guide to choosing study designs for real-world settings. [PDF]

BMC Med Res Methodol
Innocent DC, Innocent RC, Anyakorah PE, Innocent IP, Chukwuemeka PS, Anuwe JC, Eugene CF, Udoh OU, Nwokeji CE, Emerole CO, Chukwuocha UM, Dozie INS.   +11 more
europepmc   +1 more source

Lachnospiraceae in the Food–Gut Axis: A Critical Review of Dietary Modulation, Immune Regulation, and Translational Barriers

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 6, November 2026.
ABSTRACT The interplay between diet, gut microbiota, and host immunity is central to food science. The Lachnospiraceae family ferments dietary fibers to produce short‐chain fatty acids (SCFAs), notably butyrate and propionate, with immunomodulatory potential. This critical review distinguishes established findings from hypotheses.
Ruijun Wang, Zhiqi Li, Lina Zhang, Yuanming Pan, Zhanbiao He   +4 more
wiley   +1 more source

A Structured Narrative Review of Contemporary Dietary Strategies Following Acute Coronary Syndromes. [PDF]

J Cardiovasc Dev Dis
Cheung YL, Hamilton-Craig C, Layland J.
europepmc   +1 more source