Results 61 to 70 of about 245,585 (403)
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
PLoS ONE, 2019 INTRODUCTION:The NICE clinical guidelines on psychosocial interventions for the treatment of schizophrenia and psychosis in adults are based on the results of randomized controlled trials (RCTs), which may not be studies with a pragmatic design, leading ...
Chiara Gastaldon +6 more
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Pragmatism, Critical Theory and Business Ethics: Converging Lines
, 2019 There is a “Pragmatist turn” visible in the field of organization science today, resulting from a renewed interest in the work of Pragmatist philosophers like Dewey, Mead, Peirce, James and others, and in its implications for the study of organizations ...
M. Visser
semanticscholar +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
A Problem for Environmental Pragmatism: Value Pluralism and the Sustainability Principle
Contemporary Pragmatism, 2020 In this article, I suggest that the recently emerged perspective of environmental pragmatism encompasses self-contradicting principles. For many years, it was deemed impossible for environmental ethics to formulate justified environmental policy ...
Okke Loman
semanticscholar +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Legal Pragmatism and Intellectual Property Law [PDF]
, 2015 Legal Pragmatism has a longstanding tradition of looking at the law from a pragmatic point of view. This line of thinking is particularly well suited for analysing intellectual property (IP) and its economic implications.
Zech, Herbert
core +1 more source
, 2021 An accessible and engaging introduction to some of the key ideas in contemporary pragmatics, explaining how they have developed from and beyond the pioneering work of the philosopher Paul Grice, developing ever more sophisticated accounts of how and why the same words or behaviour mean different things in different contexts.
openaire +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source