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Drug eruption due to prasugrel hydrochloride: A case report and mini‐review
The Journal of Dermatology, 2019domain, desmoglein-1 and desmoglein-3 were not detected using ELISA. Histopathological examination of a biopsy specimen from his forearm showed subepidermal blisters containing eosinophils and neutrophils, and superficial perivascular infiltration of ...
Midori Kawasaki‐Nagano +6 more
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Profiles of Drug Substances, Excipients and Related Methodology, 2015
A comprehensive profile of prasugrel HCl is reported herein with 158 references. A full description including nomenclature, formulae, elemental analysis, and appearance is included. Methods of preparation for prasugrel HCl, its intermediates, and derivatives are fully discussed.
Mahmoud M H, Al Omari +4 more
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A comprehensive profile of prasugrel HCl is reported herein with 158 references. A full description including nomenclature, formulae, elemental analysis, and appearance is included. Methods of preparation for prasugrel HCl, its intermediates, and derivatives are fully discussed.
Mahmoud M H, Al Omari +4 more
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Research Journal of Pharmacy and Technology, 2018
The construction and performance characteristics of Prasugrel hydrochloride (PRS) selective electrodes were developed. Electrodes were based on the incorporation of PRS with pairing agents, Ammonium Molybdate (MOL) and Nessler reagent (NES). The electrodes displayed a Nernstian response with a mean calibration graphs slopes of 59.21, 27.57 mv.decade-1 ...
Amir Alhaj Sakur +3 more
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The construction and performance characteristics of Prasugrel hydrochloride (PRS) selective electrodes were developed. Electrodes were based on the incorporation of PRS with pairing agents, Ammonium Molybdate (MOL) and Nessler reagent (NES). The electrodes displayed a Nernstian response with a mean calibration graphs slopes of 59.21, 27.57 mv.decade-1 ...
Amir Alhaj Sakur +3 more
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Concomitant Polymorphism of Prasugrel Hydrochloride in Reactive Crystallization
Industrial & Engineering Chemistry Research, 2013Concomitant polymorphism of prasugrel hydrochloride was investigated in reactive batch crystallization experiments at 20 and 40 °C.
Wei Du +8 more
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INDIAN DRUGS, 2014
The objective of this study was to investigate nanosuspensions, hydroxypropyl-β-cyclodextrin (HPβCD) complexes and SLS powders for enhancing the solubility and dissolution rate of Prasugrel HCl (PHCl) so as to reduce the fluctuations in its oral bioavailability. PHCl nanosuspensions were prepared using evaporative precipitation method.
R. K Devara +5 more
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The objective of this study was to investigate nanosuspensions, hydroxypropyl-β-cyclodextrin (HPβCD) complexes and SLS powders for enhancing the solubility and dissolution rate of Prasugrel HCl (PHCl) so as to reduce the fluctuations in its oral bioavailability. PHCl nanosuspensions were prepared using evaporative precipitation method.
R. K Devara +5 more
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Effects of Solvent on Polymorph Formation and Nucleation of Prasugrel Hydrochloride
Crystal Growth & Design, 2014Three intrinsic properties of solvent were used to evaluate the effects of solvent on polymorph formation of prasugrel hydrochloride. In situ Raman spectroscopy, FTIR, and powder X-ray diffraction were used to characterize two solvent-free polymorphs and five solvates of prasugrel hydrochloride, the two of which were reported for the first time ...
Wei Du +9 more
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Journal of Pharmaceutical and Biomedical Analysis, 2015
A fast and selective capillary electrophoresis method was developed and validated for the simultaneous determination of the hydrochloride and acetic acid content in prasugrel hydrochloride. Because of the poor chromophore, the indirect detection was chosen.
Wioleta, Maruszak, Marcin, Cybulski
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A fast and selective capillary electrophoresis method was developed and validated for the simultaneous determination of the hydrochloride and acetic acid content in prasugrel hydrochloride. Because of the poor chromophore, the indirect detection was chosen.
Wioleta, Maruszak, Marcin, Cybulski
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Process Improvements of Prasugrel Hydrochloride: An Adenosine Diphosphate Receptor Antagonist
Organic Process Research & Development, 2012An improved process for the synthesis of prasugrel hydrochloride with an overall yield of 58%, 99.9% purity, and meeting all other quality requirements is described.
Sampath Aalla +5 more
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Solution-Mediated Polymorphic Transformation of Prasugrel Hydrochloride from Form II to Form I
Industrial & Engineering Chemistry Research, 2014In situ Raman spectroscopy was applied for the analysis of the solution-mediated polymorphic transformation of prasugrel hydrochloride from the metastable form II to the stable form I. The solution concentration during the transition process was monitored by a gravimetric method.
Wei Du +8 more
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Journal of Separation Science, 2015
Prasugrel was subjected to forced degradation studies under conditions of hydrolysis (acid, base, and neutral), photolysis, oxidation, and thermal stress. The drug showed liability in hydrolytic as well as oxidative conditions, resulting in a total of four degradation products.
Dilip Kumar, Singh +4 more
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Prasugrel was subjected to forced degradation studies under conditions of hydrolysis (acid, base, and neutral), photolysis, oxidation, and thermal stress. The drug showed liability in hydrolytic as well as oxidative conditions, resulting in a total of four degradation products.
Dilip Kumar, Singh +4 more
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