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Prazosin for treatment of post-traumatic stress disorder: a systematic review and meta-analysis

CNS Spectrums, 2020
Background Prazosin has been an accepted treatment for patients with post-traumatic stress disorder (PTSD) who experience sleep disturbances, including nightmares.
C. Reist   +5 more
semanticscholar   +1 more source

Pheochromocytoma and Prazosin

Annals of Internal Medicine, 1983
Prazosin was used to control the signs and symptoms of excessive alpha-adrenergic activity in four patients with pheochromocytomas. Long-term dosage requirements were predicted by the blood pressure response to a single 1-mg oral dose. However, surgical management of the pheochromocytomas was inadequate with prazosin alone, and intravenous phentolamine
J P, Nicholson   +7 more
openaire   +2 more sources

Search for the pharmacophore in prazosin for Transport-P [PDF]

open access: yesBioorganic and Medicinal Chemistry, 2005
Partial structures of prazosin have been synthesised and tested for inhibition of Transport-P in order to identify the structural features of prazosin, which appear to be involved in binding to the putative transporter.
Patricia Ana Zunszain   +2 more
exaly   +1 more source

A Pilot, Randomized Clinical Trial of Bedtime Doses of Prazosin Versus Placebo in Suicidal Posttraumatic Stress Disorder Patients With Nightmares

Journal of Clinical Psychopharmacology, 2018
Purpose/Background Observational studies show an association between nightmares and suicide. Prazosin is proposed as a nightmare treatment. This pilot, randomized clinical trial tested whether treatment of nightmares with prazosin would reduce suicidal ...
W. McCall   +10 more
semanticscholar   +1 more source

A Pilot Trial of Prazosin, an Alpha-1 Adrenergic Antagonist, for Comorbid Alcohol Dependence and Posttraumatic Stress Disorder

Alcoholism: Clinical and Experimental Research, 2015
Background Posttraumatic Stress Disorder (PTSD) and alcohol dependence (AD) commonly co-occur and are associated with greater symptom severity and costs than either disorder alone.
Tracy L. Simpson   +8 more
semanticscholar   +1 more source

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