Results 41 to 50 of about 91,274 (241)

Pre-Analytical Error in Biochemistry Laboratory

Scholars International Journal of Biochemistry
An observational study was done for a period of 6 months from 1st January, 2023 to 30th June, 2023 in the clinical biochemistry laboratory at GCS Medical College, Hospital and Research Centre. The study delved into pre-analytical errors within clinical biochemistry laboratories, focusing on error types, their prevalence, and potential impact. The study
Kavya Chadda, Mallick Rajni Satyendra Kumar, Chinka Patel   +2 more
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Pre-analytical Errors in Haematology Laboratory of a Tertiary Care Hospital: A Cross-Sectional Study of northern Pakistan

Pakistan Armed Forces Medical Journal
Objective: To identify the types and frequency of pre-analytical errors in the haematology laboratory and to reduce these preanalytical errors by taking corrective measures. Study Design: Cross-sectional study.
Ayesha Ellahi, Sunila Tashfeen, Fahim Akhtar, Aiza Saadia, Samra Shahid, Muhammad Wasiullah Khan   +5 more
doaj   +1 more source

Characterization of analytical errors in thromboelastography interpretation

Practical Laboratory Medicine, 2021
Introduction: Interpretation of Thromboelastography (TEG) curve involves correlating patient’s clinical profile with TEG parameters and the tracing, keeping in mind the potential sources of errors, and hence requires expertise.
Tapasyapreeti Mukhopadhyay, Arulselvi Subramanian, Hara Prasad Pati, Renu Saxena   +3 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Analysis of Preanalytical Errors in Clinical Biochemistry Laboratory of a Tertiary Care Hospital: A Retrospective Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Pre-analytical phase of laboratory testing is the most susceptible phase, as errors in this phase leads to more than 50% of erroneous results and often breaches the trust of the stakeholders on the quality of the laboratory results.
Dhanalakshmi Balasundararaj, M Senthil Prabhu, S Thilagarajan, Kathiravan Rajendran   +3 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Pre-analytical errors in clinical biochemistry-a comparative study

International Journal of Clinical Biochemistry and Research, 2019
Introduction and Objectives: Laboratory testing is very important for diagnosing a disease, monitoring its progress and to monitor the response in patients to treatment. This study analyses the effects of reinforcing skill training among the laboratory personnel on the frequently occurring pre-analytical errors in clinical biochemistry samples ...
Iram Hamid, Vinitha Ramnath Pai, Raghavendra U, M H. Sheriff   +3 more
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source