Results 51 to 60 of about 345,672 (330)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Extensive validation of a combustion and pollutant emission model of a pre-chamber engine including different pre-chamber geometries

Fuel
In this work, a 0D/1D model of a single-cylinder pre-chamber spark ignition (PCSI) engine is extensively validated with experimental data in terms of performance, combustion, and emissions by varying the pre-chamber geometry and operating conditions. In the first stage, an experimental study is carried out on the PCSI engine at 1600 rpm and wide-open ...
Bozza F., Teodosio L., Krajnovic J., Sjeric M., De Bellis V., Malfi E.   +5 more
openaire   +3 more sources

Advanced rotary engine studies [PDF]

, 1980
A review of rotary engine developments relevant to a stratified charge rotary aircraft engine is presented. Advantages in module size and weight, fuel efficiency, reliability, and multi-fuel capability are discussed along with developments in ...
Jones, C.
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Combustion analysis in a natural gas engine with pre-chamber by three-dimensional numerical simulation

Nihon Kikai Gakkai ronbunshu, 2015
Highly efficient natural gas engines have been widely used in wide range of sectors from industry and transportation. However, because combustion process in gas engines with a pre-chamber is very complicated, it is difficult to experimentally investigate
Satoshi HOKIMOTO, Tatsuya KUBOYAMA, Yasuo MORIYOSHI, Toshio YAMADA   +3 more
doaj   +1 more source

Implementation and Analysis of the Pre-Chamber Ignition Concept in a SI Engine for Passenger Car Applications [PDF]

, 2023
Pablo José Martínez Hernándiz
openalex   +1 more source

Swirling combustor energy converter: H2/air simulations of separated chambers [PDF]

, 2015
This work reports results related to the “EU-FP7-HRC-Power” project aiming at developing micro-meso hybrid sources of power. One of the goals of the project is to achieve surface temperatures up to more than 1000 K, with a ΔT ≤ 100 K, in order to be ...
MINOTTI, ANGELO, TEOFILATTO, Paolo
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Peripheral Anterior Chamber Depth and Angle Measurements Using Pentacam After Implantation of Toric and Non-toric Implantable Collamer Lenses

Frontiers in Medicine, 2021
Purpose: To evaluate the characteristics of peripheral anterior chamber measurements by Pentacam after posterior implantable collamer lenses (ICL) and toric ICL (TICL) with central hole (V4c) implantation.Methods: Prospective, non-randomized consecutive ...
Jiao Zhao, Jing Zhao, Jing Zhao, Jing Zhao, Wen Yang, Huamao Miao, Huamao Miao, Huamao Miao, Lingling Niu, Lingling Niu, Lingling Niu, Jianmin Shang, Jianmin Shang, Jianmin Shang, Xiaoying Wang, Xiaoying Wang, Xiaoying Wang, Xingtao Zhou, Xingtao Zhou, Xingtao Zhou   +19 more
doaj   +1 more source