Results 111 to 120 of about 47,788 (193)
ABSTRACT Objective Hypertensive disorders of pregnancy are associated with a significantly increased risk for later cardiovascular disease. This risk is mediated by the interval development of hypertension and insulin resistance. These are preventable and/or modifiable risk factors for cardiovascular disease if affected people engage in preventive ...
Lauren H. Theilen+6 more
wiley +1 more source
ABSTRACT Introduction Abnormal placental lesions are commonly identified in stillbirth. Interpreting these lesions and their contribution to fetal demise presents significant challenges. Recommended CODAC classification does not include detailed placental examination results.
Leila Caillault+14 more
wiley +1 more source
ABSTRACT Objective To compare inspection‐informed ratings of individual maternity units published by the Care Quality Commission (CQC) with clinical outcomes and practice measures. Design Observational study using linked national maternity and administrative hospital data. Setting The English NHS.
Ian Henderson+11 more
wiley +1 more source
Maternal Immune Activation During Pregnancy and Obstetric Outcomes: A Population‐Based Cohort Study
ABSTRACT Objective Maternal immune activation has been proposed as a mechanism for adverse pregnancy outcomes, yet the mechanisms and effects of timing remain unclear. Immune disruption in early gestation may be particularly detrimental as this is an important period for placental development, which has been associated with the pathology of adverse ...
Frederieke A. J. Gigase+10 more
wiley +1 more source
ABSTRACT Objective To investigate the prevalence of hypertension and cardiovascular dysfunction 1 year postpartum in Black African women who experienced pre‐eclampsia in a low‐resource setting in Uganda. Design Prospective cohort study. Setting Tertiary referral hospital in urban Uganda.
Annettee Nakimuli+14 more
wiley +1 more source
Should the non‐canonical pathway of nitric oxide generation be targeted in hypertensive pregnancies?
Abstract Hypertension in pregnancy is prevalent, affecting around 10% of pregnancies worldwide, and significantly increases the risk of adverse outcomes for both mothers and their babies. Current treatment strategies for pregnant women with hypertension are limited, and new approaches for the management of hypertension in pregnancy are urgently needed.
Elizabeth C. Cottrell
wiley +1 more source
ABSTRACT Background Pre‐eclampsia is a leading cause of maternal and perinatal morbidity and mortality. There are several determinants of individual pregnant women's risk of developing pre‐eclampsia, including biomarkers and ultrasound markers. Objective A conceptual framework to collate and summarise the extensive body of literature on biomarkers ...
Terteel Elawad+89 more
wiley +1 more source
ABSTRACT Objective To examine whether aspirin delays gestational age at delivery (GAD) in pregnancies with placental dysfunction (PD) phenotypes (preeclampsia [PE], small‐for‐gestational‐age [SGA], placental abruption and/or stillbirth). Design A secondary analysis of a multicentre stepped‐wedge cluster randomised trial. Setting 18 maternity/diagnostic
Ioannis Papastefanou+28 more
wiley +1 more source
ABSTRACT Between 2020 and 2022 in the United Kingdom (UK), there were 45 maternal deaths from venous thromboembolism (VTE), out of more than 2 million maternities. This occurred despite extensive risk assessment and prescribing of low molecular weight heparin (LMWH) thromboprophylaxis, alongside clinicians' overestimate of risk and commitment to the ...
Laura A. Magee+9 more
wiley +1 more source
ABSTRACT Introduction Increasing evidence has highlighted bidirectional associations between mental disorders and general medical conditions, with underlying causes ranging from lifestyle habits and side effects from medications to genetic contributions. Novel methods now provide a way to estimate the shared genetic underpinnings and the possibility of
Ron Nudel+2 more
wiley +1 more source