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PEBP1 Regulates Ferroptosis in Acute Glaucoma: Targeted Therapy Using Engineered Exosomes
General schematic diagram of Spatial and Single‐Cell Transcriptomics Identifies PEBP1 as a Ferroptosis Mediator in Glaucoma: Targeted Intervention by Engineered Stem Cell Exosomes. ABSTRACT Glaucoma is the leading cause of irreversible blindness worldwide, primarily driven by the progressive loss of retinal ganglion cells (RGCs) under pathological high
Yijia Huang +13 more
wiley +1 more source
ABSTRACT Background and Aims Gestational diabetes (GDM) and preeclampsia (PE) are major complications of pregnancy. The ratio of soluble Fms‐like tyrosine kinase 1 to placental growth factor (sFlt‐1/PlGF) may predict the short‐term absence of PE in pregnant women with clinically suspected PE. The aim of this study was to determine the role of placental
Fabrizia Citro +8 more
wiley +1 more source
This protocol outlines a mixed‐methods systematic review and meta‐analysis of commercial automated insulin delivery in Type 1 diabetes pregnancy, integrating clinical outcomes with women's and clinicians' experiences, feasibility, cost and implementation evidence to inform safe, acceptable and equitable pregnancy care.
Jieli Li +5 more
wiley +1 more source
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Family history of pre‐eclampsia as a predictor for pre‐eclampsia in primigravidas
International Journal of Gynecology and Obstetrics, 1998AbstractObjective: To assess the clinical utility of knowledge of a family history of pre‐eclampsia as a predictor for the development of pre‐eclampsia in primigravid women. Methods: 368 primigravid women were prospectively recruited from the outpatients department of an obstetric teaching hospital.
Shaun Brennecke
exaly +6 more sources
The Lancet, 2021
(Abstracted from Lancet 2021;398:341–354) Preeclampsia affects approximately 3% to 5% of all pregnancies and is a substantial contributor to maternal morbidity and mortality. The hallmark features are hypertension and proteinuria, and significant complications of multiorgan injury include eclamptic seizures, pulmonary edema, epigastric pain ...
Lucy C, Chappell +3 more
openaire +2 more sources
(Abstracted from Lancet 2021;398:341–354) Preeclampsia affects approximately 3% to 5% of all pregnancies and is a substantial contributor to maternal morbidity and mortality. The hallmark features are hypertension and proteinuria, and significant complications of multiorgan injury include eclamptic seizures, pulmonary edema, epigastric pain ...
Lucy C, Chappell +3 more
openaire +2 more sources
The Lancet, 1978
Abstract Immunological tests (lymphocyte response to phytohaemagglutinin, HLA antibody production, mixed lymphocyte reaction, HLA types and degree of matching) in women with severe pre-eclampsia show that their immunological activity is reduced or suggest that there is a high degree of immunological compatibility between mother and child.
J S, Scott, D M, Jenkins, J A, Need
+7 more sources
Abstract Immunological tests (lymphocyte response to phytohaemagglutinin, HLA antibody production, mixed lymphocyte reaction, HLA types and degree of matching) in women with severe pre-eclampsia show that their immunological activity is reduced or suggest that there is a high degree of immunological compatibility between mother and child.
J S, Scott, D M, Jenkins, J A, Need
+7 more sources
The Lancet, 2005
Pre-eclampsia is a major cause of maternal mortality (15-20% in developed countries) and morbidities (acute and long-term), perinatal deaths, preterm birth, and intrauterine growth restriction. Key findings support a causal or pathogenetic model of superficial placentation driven by immune maladaptation, with subsequently reduced concentrations of ...
Sibai, B., Dekker, G., Kupferminc, M.
openaire +3 more sources
Pre-eclampsia is a major cause of maternal mortality (15-20% in developed countries) and morbidities (acute and long-term), perinatal deaths, preterm birth, and intrauterine growth restriction. Key findings support a causal or pathogenetic model of superficial placentation driven by immune maladaptation, with subsequently reduced concentrations of ...
Sibai, B., Dekker, G., Kupferminc, M.
openaire +3 more sources
The Lancet, 2016
Pre-eclampsia affects 3-5% of pregnancies and is traditionally diagnosed by the combined presentation of high blood pressure and proteinuria. New definitions also include maternal organ dysfunction, such as renal insufficiency, liver involvement, neurological or haematological complications, uteroplacental dysfunction, or fetal growth restriction. When
Mol, Ben W. J. +5 more
openaire +4 more sources
Pre-eclampsia affects 3-5% of pregnancies and is traditionally diagnosed by the combined presentation of high blood pressure and proteinuria. New definitions also include maternal organ dysfunction, such as renal insufficiency, liver involvement, neurological or haematological complications, uteroplacental dysfunction, or fetal growth restriction. When
Mol, Ben W. J. +5 more
openaire +4 more sources
The Lancet, 2010
Pre-eclampsia remains a leading cause of maternal and perinatal mortality and morbidity. It is a pregnancy-specific disease characterised by de-novo development of concurrent hypertension and proteinuria, sometimes progressing into a multiorgan cluster of varying clinical features.
Steegers, Eric +3 more
openaire +3 more sources
Pre-eclampsia remains a leading cause of maternal and perinatal mortality and morbidity. It is a pregnancy-specific disease characterised by de-novo development of concurrent hypertension and proteinuria, sometimes progressing into a multiorgan cluster of varying clinical features.
Steegers, Eric +3 more
openaire +3 more sources

