Results 41 to 50 of about 3,757,704 (310)
, 2013 A 33 year old primagravida rhesus positive woman was referred to the Emergency Department by her family doctor at 27 weeks gestation. At 25 weeks of gestation, she had been diagnosed with hypertension and was started on labetalol therapy.
Galdes, Caroline, Bugeja, Roberta
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Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection
The Anatomical Record, EarlyView.Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson +6 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Almost 5% of pregnancies are affected by immune‐mediated inflammatory diseases (IMIDs). As treatments become available, understanding their use during pregnancy is important. We aimed to describe maternal, pregnancy and infant outcomes among IMID pregnancies exposed to biologic therapies. Methods Using the Merative™ MarketScan® Commercial Database,
Leah K. Flatman +3 more
wiley +1 more source
Postpartum eclampsia of late onset [PDF]
, 2005 Pre-eclampsia and eclampsia occur in 6% to 8% of all pregnancies.1 The British eclampsia study confirmed 383 cases of eclampsia during 1992 and warned of the severe consequences of the condition.2 In 1997 Leitch and colleagues showed that over a 60 year ...
Valentine, A. +4 more
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The placental transfer of nirmatrelvir using the ex vivo human placental perfusion model
British Journal of Clinical Pharmacology, EarlyView.Aims Nirmatrelvir is an effective therapeutic option for COVID‐19 infection and is often administered after symptom onset in pregnant individuals, but few data are available on the associated fetal exposure. The placental perfusion model evaluates maternal–fetal drug transfer across the human placenta and thus can determine fetal drug exposure.
Magdalene Zabek +5 more
wiley +1 more source
Cells, 2022 The pathophysiology of pre-eclampsia involves two major pathways, namely systemic oxidative stress and subsequent generalised inflammatory response, which eventually culminates in endothelial cell injury and the syndrome of pre-eclampsia with multi-organ
Zaleha Abdullah Mahdy +4 more
doaj +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim To quantify the prevalence of pregnancy‐, lactation‐ and reproductive potential‐related eligibility criteria in cardiovascular clinical trials and to evaluate whether they are supported by drug‐specific safety data. Methods We analysed randomized phase 3 and phase 4 cardiovascular clinical trials registered on ClinicalTrials.gov between 1 January ...
Jera Gurakuqi +6 more
wiley +1 more source
Higher Circulating Lymphocytes and the Incidence of Pre-eclampsia and Eclampsia
Journal of PregnancyExcessive immune activation contributes to the onset of early dysfunction of the maternal-fetal interface, and it is closely linked to the development of pre-eclampsia.
Qiuping Zhao +8 more
doaj +1 more source
Anaesthesia and pre-eclampsia [PDF]
Canadian Journal of Anaesthesia, 1987 Pre-eclampsia remains a major cause of maternal and fetal mortality but many complications can be prevented by appropriate intervention. The anaesthetist should play a role in the overall as well as anaesthetic management of these patients. Epidural analgesia remains the method of choice for pain relief in pre-eclamptic patients during labour. Epidural
openaire +2 more sources
Annals of the Child Neurology Society, EarlyView.ABSTRACT Introduction GRIA2 encodes the GluA2 ionotropic α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit. Pathogenic GRIA2 variants cause epilepsy, developmental delay, and neurobehavioral disorders. Characterizations of clinical features, including seizure types and their treatments, in patients with GRIA2‐related ...
Sai Srihitha Dommata +9 more
wiley +1 more source