Results 91 to 100 of about 3,065,240 (256)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Pre-Emergence Crabgrass Control
, 1963 Guide with discusses reasons and methods to control pre-emergence of ...
Macksam, William G. +2 more
core +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 1995 Emergence is the process of making properties which were not explicitly represented in a computational system explicit. This paper presents two approaches to graphical emergence suitable or implementation in a CAAD system. It presents processes for shape
J. Damski +5 more
core
Food safety practices of individuals before and after the emergence of COVID-19: A pre- and post-comparative analysis [PDF]
Background Recent literature highlights both beneficial and adverse effects of COVID-19 on individual food safety practices; however, the actual impact remains unverified, especially in low-resource countries.
Md Shahidul Islam +7 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Early verb development in one croatian-speaking child
, 2013 This paper shows the early development of the first approximately 50 verbs found in the recorded speech production of one Croatian girl. The aim is to analyse and interpret the child's verb development in terms of the distinction of a pre- and a ...
Katičić, Antigone
core
Emergence of wandering stable components
, 2020 We prove the existence of a locally dense set of real polynomial automorphisms of C 2 displaying a wandering Fatou component; in particular this solves the problem of their existence, reported by Bedford and Smillie in 1991.
Berger, Pierre, Biebler, Sebastien
core