Results 71 to 80 of about 1,495,331 (245)

Pre-hospital advanced airway management by experienced anaesthesiologists: a prospective descriptive study [PDF]

, 2013
INTRODUCTION: We report data from the first Utstein-style study of physician-provided pre-hospital advanced airway management. MATERIALS AND METHODS: Anaesthesiologists from eight pre-hospital critical care teams in the Central Denmark Region (a mixed ...
Else Tønnesen, Hans Kirkegaard, Leif Rognås, Troels Martin Hansen   +3 more
core   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Patients Perception and Satisfaction of the Ambulance Service (115) at Shahrekord, Iran [PDF]

, 2012
The services provided to the patients of pre-hospital emergency center and their satisfactions indicate the quality of pre-hospital emergency services. The goal of this study is to investigate the satisfaction of patients with Ambulance Service services (
baraz, Shahram., Esmaeili Vardanjani, Safar Ali., Mohammadi, Falaheddin., Ramezani, Monir., Sharifi, Mehrdad.   +4 more
core  

A cross-sectional analysis of the short-term outcomes of patients receiving prehospital treatment for symptomatic hypoglycaemia in Cape Town [PDF]

, 2015
IntroductionThere has been a growing prevalence of patients with chronic medical conditions in South Africa, diabetes mellitus being one of them. Acute symptomatic hypoglycaemia (SH) refers to decreased level of plasma glucose
Ridhaa Booley, Mohamed, Welzel, Tyson
core   +2 more sources

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Prehospital outcomes for ambulance service care: systematic review [PDF]

, 2013
Background: Ambulance service performance measurement has previously focused on response times and survival. We conducted a systematic review of the international literature on quality measures and outcomes relating to pre-hospital ambulance service care,
Booth, Andrew, Joanne, Coster, Phung, Viet-Hai, Siriwardena, A. Niroshan, Turner, Janette, Wilson, Richard   +5 more
core  

The Code Stroke: medical evaluation by a pre-hospital attention service [PDF]

, 2015
In 1996, the NINDS (National Institute of Neurological Disorders and Treatment of Acute Stroke) published targets for the management of patients with acute cerebrovascular events, setting a time of 3 h or less for administration of thrombolytics ...
Cantú Ríos, R., Clemente Córdova, María Bertha, Fernández, M., Hernández Saucedo, J. E., Mercado Longoria, Roberto, Palacios Saucedo, Gerardo del Carmen   +5 more
core   +1 more source

Pre-Hospital Advanced Life Support Education – Core Components for Pre-Hospital Professionals

Australasian Journal of Paramedicine, 2018
Introduction There is a broad evidence base supporting advanced life support (ALS) education to health care professionals to be structured, realistic and inclusive of a range of human factors. However, published literature largely focusses on ALS education within institutional settings such as hospitals and associated health care facilities, with ...
Reid, David N., Jones, Russell, Sim, Moira G.   +2 more
openaire   +3 more sources

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source