Results 211 to 220 of about 165,124 (284)

2^nd Generation Biofuel Production from Selected Agricultural Waste Resources in Ghana [PDF]

, 2012
Schmidt, Jens Ejbye, Thomsen, Sune Tjalfe   +1 more
core  

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Rapid Protein Extraction from Canola Meal Pre-Treated with Enzymatic Reactive Extrusion. [PDF]

Foods
Ghosh S, González Hernández EC, Sha X, Chow J, San Martin-Gonzalez F, Jin Q, Chen D.   +6 more
europepmc   +1 more source

Sustainability assessment of large-scale combined heat and power production based on willow in Denmark [PDF]

, 2012
Gylling, Morten, Kamp, Andreas, Østergård, Hanne   +2 more
core  

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Optimization of fermentation conditions for cellulase/xylanase production and hydrolysis conditions for efficient conversion of agricultural residues using Penicillium oxalicum UNN1. [PDF]

Bioresour Bioprocess
Zhong L, Jin F, Qin L, Feng D, Liu W, Lan Y, Li Z, Tang J, Cheng Z, Zhang T.   +9 more
europepmc   +1 more source

Optimization of microwave pretreatment on wheat straw. [PDF]

, 2012
Kádár, Zsófia, Schmidt, Jens Ejbye, Xu, Jian   +2 more
core  

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

Advanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li, Ziyu Jia, Dekun Li, Zhi‐Wen Hu, Yinghao Ding, Shengyi Zhang, Shengkun Tuo, Zhimou Yang, Huisheng Fu, Ling Wang, Man‐Di Wang   +10 more
wiley   +1 more source

Catalyst-free photodegradation of ethylparaben on surface-engineered PBT membranes: a coupled adsorption-photolysis mechanism. [PDF]

RSC Adv
Kouki N, Saleh Alomayri RA, Algreiby A, Tar H, Beji L.   +4 more
europepmc   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, EarlyView.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source