Results 101 to 110 of about 6,517,332 (327)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Vented Launch Vehicle Adaptor for a Manned Spacecraft with "Pusher" Launch Abort System

, 2017
A system, method, and apparatus for a vented launch vehicle adaptor (LVA) for a manned spacecraft with a "pusher" launch abort system are disclosed. The disclosed LVA provides a structural interface between a commercial crew vehicle (CCV) crew module ...
Vandervort, Robert E.
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Dynamic Tow Maneuver Orbital Launch Technique

, 2014
An orbital launch system and its method of operation use a maneuver to improve the launch condition of a booster rocket and payload. A towed launch aircraft, to which the booster rocket is mounted, is towed to a predetermined elevation and airspeed.
Rutan, Elbert L.
core  

New Technique of Blast Furnace Pre-Launch Research [PDF]

, 2011
The methods of pre-launch experimentations of charge mechanical trajectory in shaft top space and its emplacement on the stock surface during the loading by bell-less top charging system are examined. The methodical bases of pre-launch experimenting with

core  

Testing spacecraft charging predictions as Parker Solar Probe approaches the Sun

Astronomy & Astrophysics
Context. Surface charging must be carefully simulated and predicted for any spacecraft, but especially for those encountering highly variable plasma environments, such as spacecraft near the Sun.
Lee-Bellows D., Malaspina D., Ergun R., Deca J., Diaz-Aguado M., Liu M., Bonnell J.   +6 more
doaj   +1 more source

The Quebec rural emergency department project: a cross-sectional study of a potential two-pronged strategy in the knowledge transfer process.

PLoS ONE, 2015
IntroductionHealth services research generates useful knowledge. Promotion of implementation of this knowledge in medical practice is essential. Prior to initiation of a major study on rural emergency departments (EDs), we deployed two knowledge transfer
Mélodie-Anne Drouin, Richard Fleet, Julien Poitras, Patrick Archambault, Jean-Marc Chauny, Jean-Frédéric Lévesque, Mathieu Ouimet, Gilles Dupuis, Alain Tanguay, Geneviève Simard-Racine, Josée Gauthier, Fatoumata Korika Tounkara, Marie-Hélène Gilbert, France Légaré   +13 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Airborne direct-detection and coherent wind lidar measurements along the east coast of Greenland in 2009 supporting ESA’s Aeolus mission

, 2011
The Aeolus mission of the European Space Agency (ESA) will send the first wind lidar to space to fulfill the utmost need for global wind profile observations.
Witschas, Benjamin, Uwe Marksteiner, Stephan Rahm, Reitebuch, Oliver, Marksteiner, Uwe, Rahm, Stephan, Ines Nikolaus, Benjamin Witschas, Lemmerz, Christian, Oliver Reitebuch, Nikolaus, Ines, Christian Lemmerz   +11 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source