Results 51 to 60 of about 522,601 (266)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Discovery of Metal-poor and Distant Pre–Main Sequence Candidates in WLM with JWST
The Astrophysical Journal LettersWe present the discovery of 12 metal-poor and distant pre–main sequence (PMS) candidates in the dwarf irregular galaxy Wolf–Lundmark–Melotte ∼968 kpc away, at a present-day metallicity of [Fe/H] ∼ –0.9.
Venu M. Kalari +6 more
doaj +1 more source
The Power of Asteroseismology for Early Stellar Evolution
Frontiers in Astronomy and Space Sciences, 2019 Stars are the building blocks of planetary systems, clusters, associations, and galaxies. The evolution of stars is driven by physical processes in their interiors making theory of stellar interior structure and evolution an important ingredient of ...
Konstanze Zwintz
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Does Metallicity Affect the Protoplanetary Disk Fraction? Answers from the Outer Milky Way
The Astrophysical JournalThe role of metallicity in shaping protoplanetary disk evolution remains poorly comprehended. This study analyzes the disk fraction of 10 young (0.9–2.1 Myr) and low-metallicity (0.34–0.83 Z _⊙ ) clusters located in the outer Milky Way with ...
Sudeshna Patra +2 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
The potential of space observations for pulsating pre-main sequence stars
EPJ Web of Conferences, 2017 The first asteroseismic studies of pre-main sequence (pre-MS) pulsators have been conducted based on data from the space telescopes MOST and CoRoT with typical time bases of less than 40 days.
Zwintz Konstanze
doaj +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
The Astrophysical JournalThe surface magnetic fields of pre-main-sequence stars and zero-age main-sequence stars are notably strong, resulting in the generation of numerous spots and the emission of bright chromospheric lines.
Mai Yamashita, Yoichi Itoh, Shin Toriumi
doaj +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source