Results 141 to 150 of about 226,792 (352)

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

Haro 5-2: A New Pre-main-sequence Quadruple Stellar System

The Astronomical Journal
We have discovered that the H α emission-line star Haro 5-2, located in the 3–6 Myr old Ori OB1b association, is a young quadruple system. The system has a 2+2 configuration, with an outer separation of 2.″6 and with resolved subarcsecond inner binary ...
Bo Reipurth, C. Briceño, T. R. Geballe, C. Baranec, S. Mikkola, A. M. Cody, M. S. Connelley, C. Flores, B. A. Skiff, J. D. Armstrong, N. M. Law, R. Riddle   +11 more
doaj   +1 more source

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Adverse prognosis gene expression patterns in metastatic castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
We aggregated a cohort of 1012 mCRPC tissue samples from 769 patients and investigated the association of gene expression‐based pathways with clinical outcomes. Loss of AR signaling, high proliferation, and a glycolytic phenotype were independently prognostic for poor outcomes, and an adverse transcriptional feature score incorporating these pathways ...
Marina N. Sharifi, Eric Feng, Nicholas R. Rydzewski, Amy K. Taylor, Jamie M. Sperger, Yue Shi, Kyle T. Helzer, Matthew L. Bootsma, Viridiana Carreno, Alex H. Chang, Luke A. Nunamaker, Grace C. Blitzer, Tianfu Andy Shang, Aishwarya Subramanian, Anders Bjartell, Andreas Josefsson, Pernilla Wikström, Emily Feng, Manish Kohli, Rendong Yang, Scott M. Dehm, Eric J. Small, Rahul Aggarwal, David A. Quigley, Joshua M. Lang, Shuang G. Zhao, Martin Sjöström   +26 more
wiley   +1 more source

The Power of Asteroseismology for Early Stellar Evolution

Frontiers in Astronomy and Space Sciences, 2019
Stars are the building blocks of planetary systems, clusters, associations, and galaxies. The evolution of stars is driven by physical processes in their interiors making theory of stellar interior structure and evolution an important ingredient of ...
Konstanze Zwintz
doaj   +1 more source

H emission in pre-main sequence stars. I. An atlas of line profiles

, 1996
We present an atlas of very high resolution ( R ~ 50000) H α line profiles of 63 pre-main sequence stars, divided among 43 T Tauri stars, 18 Herbig Ae/Be stars, and 2 FU Orionis objects. H α emission is the most common and prominent spectroscopic feature
B. Reipurth, A. Pedrosa, M. Lago
semanticscholar   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

Submillimeter Variability in the Envelope and Warped Protostellar Disk of the Class 0 Protostar HOPS 358

The Astrophysical Journal
The James Clerk Maxwell Telescope (JCMT) Transient Survey recently discovered that the Class 0 protostar HOPS 358 decreased in 350 GHz continuum brightness by ∼25% over the course of 4 yr before brightening again for the next 4.
Patrick D. Sheehan, Doug Johnstone, Carlos Contreras Peña, Seonjae Lee, Gregory Herczeg, Jeong-Eun Lee, Steve Mairs, John J. Tobin, Hyeong-Sik Yun, The JCMT Transient Team   +9 more
doaj   +1 more source

Evolution of Stars of Small Masses in the Pre-Main-Sequence Stages [PDF]

, 1963
Chûshirô Hayashi, Takenori Nakano
openalex   +1 more source

Mixing at young ages: Beryllium abundances in cool main-sequence stars of the open clusters IC 2391 and IC 2602

, 2011
The determination of lithium abundances in stars of young clusters have shown that they deplete Li by different degrees during their pre-main sequence phase.
Anders, Asplund, Asplund, Asplund, Balachandran, Balachandran, Balachandran, Ballester, Baraffe, Barrado y Navascués, Barrado y Navascués, Barrado y Navascués, Bell, Bildsten, Bodenheimer, Boesgaard, Boesgaard, Boesgaard, Boesgaard, Bouvier, Butler, Castilho, Chaboyer, Chabrier, Chabrier, Chmielewski, Coelho, da Silva, Dobbie, Duncan, D’Orazi, Ford, Garcia Lopez, Garcia Lopez, Hünsch, James, Jeffries, Jeffries, Jeffries, Jones, Jones, King, King, King, L. Pasquini, MacDonald, Makishima, Martin, Martin, Mendes, Mermilliod, Patten, Piau, Pinsonneault, Platais, Primas, Prosser, R. Smiljanic, Randich, Randich, Randich, Randich, Randich, Randich, Randich, S. Randich, Santos, Sbordone, Sbordone, Sestito, Sestito, Siess, Smiljanic, Smiljanic, Smiljanic, Soderblom, Soderblom, Soderblom, Stauffer, Stauffer, Stephens, Stuik, Stütz, Takeda, van Leeuwen, Ventura, Xiong   +86 more
core   +1 more source