Results 71 to 80 of about 20,977 (265)

Sagging behavior of precast NC beams with HPCs-filled wet joints incorporating pre-stressing technique

Case Studies in Construction Materials
Precast segmental beams constructed with normal concrete (NC) are widely adopted in modern infrastructure because of their advantages in decreasing on-site labor, shortening construction time, and observing high-quality control.
Ahmed Hamoda, Galal Elsamak, Basant ramadan   +2 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Experiment and FEM Modelling of Bond Behaviors between Pre-stressing Strands and Ultra–High–Performance Concrete

Journal of Materials and Engineering Structures, 2020
The objective of this paper is to investigate the bond properties of prestressing strands embedded in Ultra–High–Performance Concrete (UHPC).The UHPC was made in laboratory using local materials in Vietnam.Its mixture contains: silica aggregates ...
Duy Hoa PHAM, Ba Danh LE, Dang Tung KHUC, Thanh Quang VU, Trong Toan KHONG, Van Trinh DO, Quy Tuan NGO   +6 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A simple way to make pre-stressed ceramics with high strength

Journal of Materiomics, 2019
A pre-stressing design and a simple fabrication technology to substantially improve the strength of ceramic components are presented. Residual surface compressive stress is generated in ceramic components by pressureless sintering of a green bulk coated ...
Yiwang Bao, Fenghua Kuang, Yi Sun, Yueming Li, Detian Wan, Zongyang Shen, Delong Ma, Lingfeng He   +7 more
doaj   +1 more source

Interface Waves in Pre-Stressed Incompressible Solids [PDF]

, 2007
We study incremental wave propagation for what is seemingly the simplest boundary value problem, namely that constitued by the plane interface of a semi-infinite solid. With a view to model loaded elastomers and soft tissues, we focus on incompressible solids, subjected to large homogeneous static deformations.
openaire   +3 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source