Results 181 to 190 of about 14,088,991 (233)

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source

Efficient Cholesteric Liquid Crystal Waveguide Polarizing Splitters for High‐Sensitivity Chip‐Scale Atomic Magnetometry

Advanced Science, EarlyView.
An integrated polarimetry architecture based on a cholesteric liquid crystal waveguide polarization splitter overcomes the volumetric bottleneck in chip‐scale atomic magnetometers. By leveraging Bragg‐selective reflection and total‐internal‐reflection‐induced helicity inversion, this ultrathin device enables efficient circular polarization splitting ...
Zhibo Cui, Chuang Wang, Xiangyang Zhou, Gaopu Hou, Jinsheng Hu, Mao Ye, Xu Xiao, Zhen Chai, Yishi Weng, Yuning Zhang   +9 more
wiley   +1 more source

Origin of Enhanced Efficiency and Reduced Roll‐Off in Organic Light‐Emitting Diodes Based on Pt(II) Complexes

Advanced Science, EarlyView.
Controlled Pt–Pt fine structure in square‐planar Pt(II) complexes governs metal–metal‐to‐ligand charge‐transfer (MMLCT) state formation, exciton dynamics, and organic light‐emitting diode performance. Short Pt–Pt contacts in Pt(fppz)2 enable coherent metal–metal coupling, sub‐microsecond emission and an external quantum efficiency of 29%, whereas ...
Atul Shukla, Sarah K. M. McGregor, Julian A. Steele, Innes K. Gale, Kiyoshi Miyata, Monirul Hassan, Christian McDonald, Romain J. Lepage, Eduardo Solano, Pilankatta K. Ramya, Cherumuttathu H. Suresh, Takumi Ehara, Chihaya Adachi, Ken Onda, Shih‐Chun Lo, Ebinazar B. Namdas   +15 more
wiley   +1 more source

p300‐Mediated H3K18 Lactylation Drives Radiation‐Induced Pulmonary Fibrosis via VIRMA‐Dependent m6A Modification of GATA3

Advanced Science, EarlyView.
Radiation triggers glycolytic reprogramming in alveolar epithelial type II cells, causing pathological lactate accumulation. This metabolic stress drives p300‐mediated H3K18 lactylation at the VIRMA promoter, activating transcription. Elevated VIRMA enriches m6A on GATA3 mRNA, which YTHDF1 stabilizes, ultimately driving epithelial–mesenchymal ...
Junxuan Yi, Mingwei Wang, Duo Yu, Mingqi Zhao, Xinyan Wang, Shiqi Li, Xiaowen Han, Wei Wei, Shunzi Jin   +8 more
wiley   +1 more source

A Synthetic Platform for Antibody Junctional Diversification Beyond Natural Constraints

Advanced Science, EarlyView.
ARESEC is a synthetic platform that reconstructs functional V(D)J recombination in HEK293T cells. By introducing RSS elements and co‐expressing RAG1/2 and TdT across all three antibody CDRs, it enables programmable junctional diversification and direct generation of high‐affinity variants targeting PD‐1/PD‐L1, overcoming the evolutionary constraints of
Wang Liu, Jun Yang, Yuhang Zhang, Xiaoli Xue   +3 more
wiley   +1 more source

Pre-synchronization Control of Grid-connected Three-phase Inverters Based On the Characteristics of Synchronous Generators

2020 15th IEEE Conference on Industrial Electronics and Applications (ICIEA), 2020
A pre-synchronization control strategy for grid-connected three-phase inverters is proposed in this paper ,to solve the problem of slow response of the conventional synchronous unit containing a phase-locked loop (PLL), based on the synchronization principle between the synchronous generator (SG) terminal voltage and the grid voltage when there is no ...
Shiqiang Xiang, Shuting Li, Songrong Wu, Zizhan Li   +3 more
openaire   +2 more sources

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Pre-Synchronization Control Strategy for Grid Connection of Synchronverter Cluster

2021 IEEE 4th International Electrical and Energy Conference (CIEEC), 2021
It is found that large inrush currents and power oscillations occur when a synchronverter cluster is connected to the utility grid. In this paper, we propose a pre-synchronization control strategy to minimize the inrush current and suppress the power oscillation in the grid-tied synchronverters.
Yingjie Tan, Xia Shen, Min Xu
openaire   +1 more source

Combined Pre-Synchronization and Power Sharing Control for Microgrid Applications

2020 55th International Universities Power Engineering Conference (UPEC), 2020
With the increased penetration of distributed generation in the power distribution systems, it becomes a requirement for microgrids to switch between islanding and grid-connected operation modes. When the line impedance of each micro-source in the microgrid is different, this will cause a mismatch in the output power of the micro-sources.
L Lei, Mohammed Elgendy, N Wade, Salaheddine Ethni   +3 more
openaire   +1 more source

Research on Pre-Synchronization Control Strategy for Microgrid VSG Inverter

2019 14th IEEE Conference on Industrial Electronics and Applications (ICIEA), 2019
In the microgrid, the virtual synchronous generator (VSG) technology realizes the friendly access of the distributed power supply and improves the stability of the power system by simulating the operating mechanism of the synchronous generator (SG). However, the VSG inverter has a large impact current at the moment when it is switching from off-grid to
Mengxiang Zhang, Minchao Liu, Xuemei Zheng, Haoyu Li, Yanxue Yu, Zhenwei Li   +5 more
openaire   +1 more source