Results 51 to 60 of about 475,340 (247)

Inappropriate testing for the diagnosis of coronary artery disease

Italian Journal of Medicine, 2015
In the last three decades also in our country there has been a huge growth in the use of non-invasive testing for diagnosis of coronary artery disease (CAD). Therefore, appropriateness of prescription in diagnostic testing is crucial. Clinical evaluation
Giuseppe Di Pasquale, Gloria Vassilikì Coutsoumbas, Silvia Zagnoni   +2 more
doaj   +1 more source

Atypical Endometrial Hyperplasia and Unexpected Cancers at Final Histology: A Study on Endometrial Sampling Methods and Risk Factors

Diagnostics, 2020
Background: Up to 40% of women with atypical endometrial hyperplasia (AEH) can reveal endometrial cancer (EC) at hysterectomy. The pre-operative endometrial sampling method (ESM) and some independent cancer predictors may affect this outcome. The present
Luca Giannella, Giovanni Delli Carpini, Francesco Sopracordevole, Maria Papiccio, Matteo Serri, Giorgio Giorda, Dimitrios Tsiroglou, Anna Del Fabro, Andrea Ciavattini   +8 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

A Bayesian decision support sequential model for severity of illness predictors and intensive care admissions in pneumonia

BMC Medical Informatics and Decision Making, 2019
Background Community-acquired pneumonia (CAP) is one of the leading causes of morbidity and mortality in the USA. Our objective was to assess the predictive value on critical illness and disposition of a sequential Bayesian Model that integrates Lactate ...
Amado Alejandro Baez, Laila Cochon, Jose Maria Nicolas   +2 more
doaj   +1 more source

Rational use of Xpert testing in patients with presumptive TB: clinicians should be encouraged to use the test-treat threshold

BMC Infectious Diseases, 2017
Background A recently published Ugandan study on tuberculosis (TB) diagnosis in HIV-positive patients with presumptive smear-negative TB, which showed that out of 90 patients who started TB treatment, 20% (18/90) had a positive Xpert MTB/RIF (Xpert) test,
Tom Decroo, Aquiles R. Henríquez-Trujillo, Anja De Weggheleire, Lutgarde Lynen   +3 more
doaj   +1 more source

Non-invasive imaging criteria for the diagnosis of hepatocellular carcinoma in non-cirrhotic patients with chronic hepatitis B

JHEP Reports, 2021
Background & Aims: Criteria defined by the European Association for the Study of the Liver (EASL) and Liver Imaging Reporting and Data System (LI-RADS) enable hepatocellular carcinoma (HCC) diagnosis based on imaging in cirrhosis.
Carlos Moctezuma-Velázquez, Sara Lewis, Karen Lee, Salvatore Amodeo, Josep M. Llovet, Myron Schwartz, Juan G. Abraldes, Augusto Villanueva   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Emergency measures in the diagnosis and treatment of chronic forms of ischemic heart disease

Терапевтический архив
Coronary heart disease (CHD) is one of the most common cardiovascular diseases and the most common cause of death in Russia. Primary diagnostics of CHD involves assessing the pre-test probability of CHD. Thereafter, myocardial ischemia should be verified
Sergey A. Boytsov, Sergei I. Provatorov, Irina I. Shestova, Natalia N. Nikulina   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Prediction of obstructive coronary artery disease in people living with HIV: value of machine learning incorporating HIV-specific factors

Frontiers in Medicine
ObjectivesTo explore the value of machine learning (ML) model in conjunction with HIV-specific risk factors to predict obstructive coronary artery disease (CAD) (≥50% stenosis) on coronary CT angiography (CTA) in the asymptomatic people living with HIV ...
Hui Liu, Hui Liu, Haibo Ding, Haibo Ding, Haibo Ding, Yue Zheng, Yue Li, Yang Yu, Zhaodi Geng, Jie Zhou, Huaibi Huo, Han Li, Xin Peng, Xin Peng, Zhaoxin Tian, Xiaolin Li, Xiaolin Li, Xiaolin Li, Hong Shang, Hong Shang, Hong Shang, Ting Liu   +21 more
doaj   +1 more source