Results 61 to 70 of about 4,914 (173)

TFAM‐Mediated mtDNA Replication is Essential for Developmental Competence of In Vitro Grown Oocytes

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Purpose Mitochondria are essential for oocyte maturation and early embryonic development, supplying ATP and maintaining mitochondrial DNA (mtDNA) integrity. During oogenesis, mtDNA undergoes dramatic amplification, but the mechanisms and functional significance of this process remain unclear. The purpose of this study was to elucidate the role
Son Quang Do, Hidetaka Tasaki, Hiroaki Funahashi, Takuya Wakai   +3 more
wiley   +1 more source

Vitamin D3 Regulates Follicular Development and Intrafollicular Vitamin D Biosynthesis and Signaling in the Primate Ovary

Frontiers in Physiology, 2018
There is an increasing recognition that vitamin D plays important roles in female reproduction. Recent studies demonstrated that 1α,25-dihydroxyvitamin D3 (VD3), the biologically active form of vitamin D, improved ovarian follicle survival and growth in ...
Jing Xu, Jing Xu, Maralee S. Lawson, Fuhua Xu, Yongrui Du, Yongrui Du, Olena Y. Tkachenko, Cecily V. Bishop, Lucas Pejovic-Nezhat, David B. Seifer, Jon D. Hennebold, Jon D. Hennebold   +11 more
doaj   +1 more source

The Regulation of Apoptosis in Preantral Ovarian Follicles

Neurosignals, 2000
Less than 1% of ovarian follicles ever mature to ovulation. The remainder undergo atretic degeneration via apoptosis during development. Though the regulation of antral and preovulatory survival has been studied for many years, very little is known about the regulation of survival and development of preantral follicles.
openaire   +2 more sources

The Role of Anethole in Reproductive Physiology and In Vitro Biotechnologies—A Review

Reproduction in Domestic Animals, Volume 61, Issue 1, January 2026.
ABSTRACT In vitro reproductive biotechnologies show promise for fertility preservation but still face challenges, including oxidative stress from high oxygen tension, which impairs cell viability and development. Antioxidants have been widely explored to attenuate oxidative stress during culture.
André Luiz da Conceição‐Santos, José Ricardo de Figueiredo   +1 more
wiley   +1 more source

Cytomolecular and In Vitro Toxicity Studies on Bisphenol A Effect on Ovine Granulosa Cells

Veterinary Medicine International, Volume 2026, Issue 1, 2026.
Bisphenol A (BPA), an organic environment chemical, has extensive presence in consumer goods and food/feed items. The present study aimed to explore how BPA influenced the viability, proliferation, apoptosis, and steroidogenic activity of ovine ovarian granulosa cells (GCs).
Poonam Kumari Singh, Bogapathi Sampath Kumar, Sumanta Nandi, Paluru Subramniyam Parameswara Gupta, Sukanta Mondal, Imtiaz Rabbani   +5 more
wiley   +1 more source

In Vitro Gamete Production in Mammals: Decades of Pioneering Approaches in Germ Cell and Stem Cell Biology Supporting Innovative Discovery and Expansion of Human Reproductive Potential

Molecular Reproduction and Development, Volume 92, Issue 12, December 2025.
ABSTRACT During recent decades a myriad of approaches have emerged for generating surrogate gametes or achieving in vitro gametogenesis (IVG). The most recent approaches to IVG include the development of increasingly complex culture systems, use of companion cells combined with germ line cells in two‐ or three‐dimensional configurations, derivation of ...
Keith E. Latham
wiley   +1 more source

DTPA disrupts development of preantral ovarian follicles in vitro

Reproduction and Fertility
Dietary zinc deficiency disrupts fertility in vivo by impairing oocyte and embryo development near ovulation. Acute treatment of newborn ovaries with a strong intracellular chelator (TPEN), which preferentially binds zinc, disrupts follicular development.
James M Hester, Francisco J Diaz
doaj   +1 more source

Sphingosine 1-phosphate promotes activation of aprine preantral follicle in vitro

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2014
This study describes the effect of sphingosine 1-phosphate (S1P) for development of preantral follicle, therefore the activation and follicular viability of caprine follicles cultured in vitro.
J.E. Nóbrega Jr., R. Rossetto, M.H.T. Matos, R.N. Chaves, D.M. Magalhães, I.B. Lima-Verde, S.N. Báo, C.C. Campello, J.R. Figueiredo, P.B.D. Gonçalves, J.F.C. Oliveira   +10 more
doaj   +1 more source

The Critical Role of Enhanced OXPHOS and Mitochondrial Hyperpolarization in Simulated Microgravity‐Induced Oocyte Maturation Arrest

Advanced Science, Volume 12, Issue 38, October 13, 2025.
Simulated microgravity induces distinct mitochondrial hyperactivation patterns‐elevated OXPHOS and MMP‐which accelerate meiosis without SAC failure but delays MTOC coalescence, leading to spindle defects and meiotic arrest. Prolonging M‐phase restores MTOC assembly and oocyte maturation.
Lei Ge, Yuqing Gao, Feifei Du, Chiyuan Ma, Tianxia Xiao, Yali Yang, Xiaohua Lei, Jian V. Zhang   +7 more
wiley   +1 more source

Vitrification affects the expression of matrix metalloproteinases and their tissue inhibitors of mouse ovarian tissue

Iranian Journal of Reproductive Medicine, 2016
Background: One of the most major obstacles of ovarian tissue vitrification is suboptimal developmental competence of follicles. Matrix metalloproteinases 2 (MMP-2) and 9 (MMP-9) and their tissue inhibitors TIMP-1 and TIMP-2 are involved in the ...
Reza Asadzadeh, Shima Khosravi, Saeed Zavareh, Mohammad Taghi Ghorbanian, Seyed Hassan Paylakhi, Seyed Reza Mohebbi   +5 more
doaj