Results 131 to 140 of about 31,572 (245)

Integrin α5β1‐mediated multicellular crosstalk in the tumor microenvironment drives bladder cancer progression and reveals targetable vulnerabilities

open access: yesiMetaOmics, Volume 3, Issue 2, June 2026.
Integrating multiplexed immunofluorescence, animal models, and clinical samples, our single‐cell and spatial atlas maps tumor microenvironment evolution during bladder cancer (BCa) progression. We reveal that stemness‐associated tumor cells (SDC1+), POSTN+ myofibroblastic cancer‐associated fibroblasts (mCAFs), and immunosuppressive monocytic myeloid ...
Ting Liang   +13 more
wiley   +1 more source

Diagnostic Accuracy of Entropy Based Image Analysis of Cervical Precancerous Cells

open access: yesJournal of Biophotonics, Volume 19, Issue 6, June 2026.
This work studies the correlation between the Bragg‐Williams order parameter (S2), as measured from a digital slide image, and the cytopathologic diagnoses of squamous cervical cytology and demonstrates the diagnostic accuracy of the S2 classification model. This image is an example of this approach for a “carcinoma in situ” cell image and demonstrates
Jennifer Makin   +3 more
wiley   +1 more source

Sublineage‐Specific A45S Polymorphism Alters the Biological Function of the Human Papillomavirus 11 E7 Protein

open access: yesJournal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT The E7 oncoprotein of human papillomavirus (HPV) plays a crucial role in viral pathogenesis and replication. Although it is generally highly conserved across HPV genotypes, naturally occurring E7 variants can display functional differences that may affect viral persistence, oncogenic potential, and host cellular responses.
Zsolt Barnabás Éles   +8 more
wiley   +1 more source

Cutaneous Squamous Cell Carcinoma Amongst Solid Organ Transplant Recipients: A Systematic Review of Molecular Alterations

open access: yesJEADV Clinical Practice, Volume 5, Issue 2, Page 433-457, June 2026.
ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray   +8 more
wiley   +1 more source

Unraveling Oral Dysbiosis: Microbial Complexity in Common Oral Diseases

open access: yesMicrobiologyOpen, Volume 15, Issue 3, June 2026.
The oral microbiome undergoes dynamic establishment from birth, maturing into a resilient ecosystem. Perturbation of this homeostasis—driven by dietary, immunological, and anatomical factors—triggers dysbiosis, which underpins the pathogenesis of major oral diseases, including dental caries, periodontal disease, salivary gland disorders, oral mucosal ...
Zixi Kang   +8 more
wiley   +1 more source

Essential Oils and Their Multifunctional Activities Against Pseudomonas aeruginosa: Current Evidence and Perspectives

open access: yesMicrobiologyOpen, Volume 15, Issue 3, June 2026.
Essential oils show multifunctional activity against multidrug‐resistant Pseudomonas aeruginosa by targeting bacterial membranes, quorum sensing, biofilm formation, virulence traits, and antibiotic susceptibility. Their translational potential depends on standardized composition, optimized delivery systems, safety assessment, and clinical validation ...
Giorgia Novello   +15 more
wiley   +1 more source

Organoids: From Bench to Bedside Applications

open access: yesMedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li   +6 more
wiley   +1 more source

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