Results 81 to 90 of about 3,527 (306)
A hybrid optimization approach for setup planning with tolerance constraints
MATEC Web of Conferences, 2018 Computer-aided process planning (CAPP) plays an important role in integrated manufacturing system and it can serve as a bridge between CAD and CAM. As a crucial part of CAPP, setup planning is a multi-constraint problem, in which the precision takes ...
Wu Wenbo, Zeng Jiani, Huang Zhengdong
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Precedence-constrained covering problems with multiplicity constraints
, 2023 We study the approximability of covering problems when the set of items chosen to satisfy the covering constraints must form an ideal of a given partial order. We examine the general case with multiplicity constraints, where item i can be chosen up to di
Skarlatos, A., Kolliopoulos, S.G.
core
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Modelling construction scheduling constraints using shapes constraint language (SHACL) [PDF]
, 2019 This paper presents a new approach for modelling construction scheduling constraints using Shapes Constraint Language. Current modelling approaches focuses on modelling precedence and discrete constraints at master planning or phase planning level and ...
Ranjith K Soman, K Soman, Ranjith
core +1 more source
An Improved Variable Neighborhood Search for the Reconfigurable Assembly Line Reconfiguring Problem
Applied SciencesThroughout the past several decades, the manufacturing industry has been confronted with rapidly evolving market demands. The Reconfigurable Assembly Line (RAL) changes the quantity and variety of products produced through reconfiguration at different ...
Xiaojun Zhu +3 more
doaj +1 more source
Locating service centers with precedence constraints
Discrete Applied Mathematics, 1993 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Y. Kaufman, Arie Tamir
openaire +2 more sources
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
PLoS ONE, 2018 The present study explored the sensitivity towards bimanual end-state comfort in a task that required anticipating different final grips. Participants simultaneously reached and grasped two objects with either a whole-hand grip (WHG) or a precision grip (
Christian Seegelke, Matthias Weigelt
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source