Results 131 to 140 of about 763,867 (328)
CX3CL1 in Early Detection of Alzheimer's Disease: Plasma Dynamics Across Age and Disease Stages
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Backgrounds Alzheimer's disease (AD) is characterized by amyloid‐beta plaques, tau tangles, and neuroinflammation. C‐X3‐C motif chemokine ligand 1 (CX3CL1, also known as fractalkine), a neuroimmune chemokine implicated in AD pathogenesis, shows inconsistent alterations in plasma/serum across studies.
Ling Wang +6 more
wiley +1 more source
Legal Precedent: A Theoretical and Empirical Analysis [PDF]
The use of precedents to create rules of legal obligation has, to our knowledge, received little theoretical or empirical analysis. This paper presents and tests empirically an economic approach to legal precedent that is derived mainly from the analysis
Richard A. Posner, William M. Landes
core
Tyson Foods, Inc. v. Bouaphakeo: The Use of Statistical Evidence in Class Actions [PDF]
, 2016 Statistical analysis potentially plays an important role in class-action litigation, but the use of such evidence is limited at the class-certification stage of such suits.
Zhang, Wenbo
core +1 more source
Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende +26 more
wiley +1 more source
LA SENTENCIA JUDICIAL COMO MEDIO DE PRUEBA THE VEREDICT AS EVIDENCE
Revista Chilena de Derecho, 2012 Este trabajo explica la proyección probatoria que tiene una sentencia firme y ejecutoriada en el proceso civil chileno. Como acto procesal, la decisión judicial conforma una realidad jurídica y material que puede servir para acreditar un hecho en un ...
Alejandro Romero Seguel
doaj
TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara +18 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose Air pollution has been linked to several neurological conditions, including stroke and neurodegenerative diseases. Evidence regarding its association with multiple sclerosis (MS) remains conflicting, limited by small sample sizes. Methods PubMed, Embase, Scopus, and Cochrane controlled register of trials (CENTRAL) were searched on ...
Ahmad A. Toubasi, Thuraya N. Al‐Sayegh
wiley +1 more source
Overruling and the Instability of Law [PDF]
We investigate the evolution of common law under overruling, a system of precedent change in which appellate courts replace existing legal rules with new ones.
Andrei Shleifer, Nicola Gennaioli
core
Stop the \u3ci\u3eStop the Beach\u3c/i\u3e Plurality! [PDF]
, 2011 The plurality opinion in Stop the Beach Renourishment v. Florida Department of Environmental Protection articulated a new doctrine of judicial takings, and justified it with arguments drawing on text, history, precedent, and common sense.
Byrne, J. Peter
core +1 more source