Results 61 to 70 of about 656,064 (285)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Importance of judicial decisions as a perceived level of relevance
Utrecht Law Review, 2020 Studies employing network analysis to reveal hidden mechanisms in judicial decision making, both in common law as well as civil law countries often use rather vague concepts of ‘importance’ of judicial decisions, concepts that are not always thoroughly ...
Terezie Smejkalová
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Willful Infringement and the Evidentiary Value of Opinion Letters After Knorr–Bremse v. Dana [PDF]
, 2005 Recently, the Federal Circuit in Knorr-Bremse v. Dana overruled almost twenty years of precedent by striking down the adverse inference doctrine, which had created a negative presumption against any alleged patent infringer for failing to obtain and ...
Stowell, Joshua
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
US legal system in the context of English legal heritage and theory of the natural rights of John Locke [PDF]
Strani pravni život, 2018 The paper discusses several characteristics of the US legal system that rest upon English legal heritage, brought from England to North America by the first colonists.
Bekčić-Pješčić Gordana
doaj
Revista Eletrônica de Direito Processual, 2020 The present essay examines the nature of the creation activities contained in the decisions listed in article 927 of the Brazilian Civil Procedure Code of 2015 (BCPC/15) and its possible consequences for the Brazilian constitutional jurisdiction, as well
Romulo Ponticelli Giorgi Júnior
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Revista Chilena de Derecho, 2010 Se discute el impacto de las decisiones del Tribunal Constitucional, en su rol de supremo intérprete de la Constitución, sobre los demás poderes del Estado, particularmente sobre el Gobierno y el Congreso, en especial cuando sus sentencias versan sobre ...
GONZALO CARREÑO PAVEZ +1 more
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North to the Future of the Right to Bear Arms: Analyzing the Alaska Firearms Freedom Act and Applying Firearm Localism to Alaska [PDF]
, 2016 The Second Amendment has gone from a rarely invoked constitutional provision to being one of the most hotly contested and politically charged protections of the Bill of Rights.
Hill, John
core +1 more source