Results 61 to 70 of about 107,682 (311)
Precedent, Humility, and Justice [PDF]
, 2012 When resolving cases, appellate courts must quickly decide how much respect to give precedent decisions and the analytical approaches they embody. While the logical and philosophical justifications for reliance on precedent have been frequent topics in ...
Gentithes, Michael
core +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Notice condition precedent to claim liquidated ascertained damages (LAD) [PDF]
, 2011 Most forms of building contract include a clause entitling the employer to a specified amount of damages, referred to as liquidated and ascertained damages (LAD) if the contractor is late in constructing a project.
Mansor, Nur Syaimasyaza
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Constitutive Rules of Precedent [PDF]
, 2023 © 2022. This document is made available under the CC-BY-SA 4.0 license http://creativecommons.org/licenses/by-sa/4.0/ This document is the published version of a published work that appeared in final form in Revus, Journal for constitutional theory and ...
Nuñez Vaquero, A.
core
Importance of judicial decisions as a perceived level of relevance
Utrecht Law Review, 2020 Studies employing network analysis to reveal hidden mechanisms in judicial decision making, both in common law as well as civil law countries often use rather vague concepts of ‘importance’ of judicial decisions, concepts that are not always thoroughly ...
Terezie Smejkalová
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
US legal system in the context of English legal heritage and theory of the natural rights of John Locke [PDF]
Strani pravni život, 2018 The paper discusses several characteristics of the US legal system that rest upon English legal heritage, brought from England to North America by the first colonists.
Bekčić-Pješčić Gordana
doaj