Results 71 to 80 of about 656,064 (285)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
RACIAL SEGREGATION AS A MANIFESTATION OF IDEOLOGICAL EXTREMISM: THE EXAMPLE OF THE CASE “PLESSY V. FERGUSON” [PDF]
Legal BulletinRelevance. The topic of racial segregation and the struggle for civil rights in the United States continues to be relevant. Precedential decisions of the US Supreme Court on issues of racial segregation still influence the development of American society
KHAPCHAEV S.T., KOKOREV V.G.
doaj +1 more source
Impeachment as Congressional Constitutional Interpretation [PDF]
, 2000 Katyal argues that one can adhere to originalism in the context of judicial interpretation and, nevertheless, believe in a broader style of interpretation for the legislature. He illustrates the point with three examples--the roles of history, precedent,
Katyal, Neal Kumar
core +1 more source
A New Basis Function Approach to 't Hooft-Bergknoff-Eller Equations [PDF]
, 1999 We analytically and numerically investigate the 't Hooft-Bergknoff-Eller equations, the lowest order mesonic Light-Front Tamm-Dancoff equations for U(N_C) and SU(N_C) gauge theories.
A. Duncan +22 more
core +4 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
The Evolution of Precedent [PDF]
We evaluate Richard Posner's famous hypothesis that common law converges to efficient legal rules using a model of precedent setting by appellate judges. Following legal realists, we assume that judicial decisions are subject to personal biases, and that
Andrei Shleifer, Nicola Gennaioli
core
Habeas Corpus: Fourth Circuit Allows Writ to Issue to State Prisoner Not Yet Serving Sentence Under Attack [PDF]
, 1966 By manipulating the concept of custody to include the legal effects of a conviction precedent to service of sentence, the Fourth Circuit has extended the use of the writ of habeas corpus into new and perhaps questionable ...
core +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source