Results 61 to 70 of about 1,356,070 (297)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

POPULISM IN POLITICAL DISCOURSE: DIAGNOSTIC FEATURES AND LINGUO-COGNITIVE TECHNIQUES OF FORMATION

Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2019
The article deals with the semantics of the term “populism” and its re-lexicalization via changing the meaning from neutral to negative. The author gives examples of the third-wave American populist leaders’ speeches, namely those made by Ugo Chaves ...
Lilia V. Moiseenko
doaj   +1 more source

NATO's "humanitarian intervention" in Kosovo: legal precedent or aberration?

, 2009
NATO's intervention in Kosovo in 1999 (Operation Allied Force) is one of the seminal events in contemporary international relations. While the humanitarian aspect of this intervention was widely endorsed the dominant view is that NATO acted illegally ...
Hehir, A., Aidan Hehir
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

National-precedent name of Lesia Ukrainka woman in the reception of speakers

, 2020
Автор статті вивчає феномен прецедентної особистості Лесі Українки як культурно значущого явища національно-мовної картини світу українців у рецепції сучасних мовців.
Петренко, А., Anastasiia Petrenko   +1 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Resignation: Expressive Semantic Evolution of a Borrowing and a Precedent Name

Научный диалог
This article explores the narrowly used borrowing from French, résignation (with Russian graphic variants rezinyatsiya and rezignatsiya), which paradoxically combines features of exoticism, neologism, and archaism in contemporary Russian.
A. V.  Sharavin, O. E. Voronichev, I. L. Startseva   +2 more
doaj   +1 more source

Populism as a Concept and the Challenge of U.S. History

IdeAs, 2019
This paper explores the viability of populism as both a historical category and a political concept. Its starting point is the historical example of the first mass political expression that formed under the name of populism, and that was the U.S.
Charles Postel
doaj   +1 more source

Dynamic reconfiguration of the language network preceding onset of speech in picture naming [PDF]

Human Brain Mapping, 2014
Abstract Language production is a complex neural process that requires the interplay between multiple specialized cortical regions. We investigated modulations in large‐scale cortical networks underlying preparation for speech production by contrasting cortico‐cortical coherence for overt and silent picture naming
Liljeström Mia, Salmelin Riitta, Liljeström Mia, Liljeström Mia, Stevenson Claire, Kujala Jan   +5 more
openaire   +5 more sources

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source