Results 41 to 50 of about 264,902 (287)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Revista Eletrônica de Direito Processual, 2015 This article analyses the judicial precedents and the principle of integrity in the Brazilian legal system. First, an overview of the conception of “law as integrity” elaborated by Ronald Dworkin is outlined.
Anna Flávia Magalhães de Caux Barros +1 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
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Crime of Genocide before the Hague International Court [PDF]
Zbornik Radova Pravnog Fakulteta u Splitu, 2016 The I.C.J. has dealt so far with three cases in which its jurisdiction was claimed to be based on Article IX of the 1948 Genocide Convention. In all these cases was involved the Federal Republic of Yugoslavia (FRY).
Vladimir-Đuro Degan
doaj
How Cost of Attendance Stipends are Creating New Precedents in NCAA Athletics [PDF]
, 2020 The problem being tested is: How are the new Cost of Attendance (COA) stipends implemented in 2015 affecting spending on women's and men's non-revenue sports? The problem will be explored through data collected on all FBS and FCS Division I schools.
DeCort, Callie
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Autoprecedente y creación de precedentes en el tribunal supremo
Teoria Jurídica Contemporânea, 2017 RESUMEN: Este trabajo pretende mostrar cómo el mejor o peor cumplimiento de la regla del auto-precedente en un Tribunal Supremo puede repercutr en la efcacia de su función de creación de precedentes para el resto de tribunales. Tras caracterizar el auto-
Marina Gascón
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Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
A relevância dos precedentes para a eficiência da justiça no Brasil
Revista CNJ, 2019 O artigo examina o papel do Supremo Tribunal Federal na criação (e eventual superação) de precedentes, principalmente a partir de sua regulação pelo atual Código de Processo Civil (Lei nº 13.105/2015).
Oscar Valente Cardoso
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