Results 41 to 50 of about 20,213 (267)
Pediatric Blood &Cancer, EarlyView.ABSTRACT We report a retrospective single‐center analysis of pediatric patients with relapsed or refractory B‐cell precursor acute lymphoblastic leukemia focusing on relapses outside of the typical locations, bone marrow, central nervous system, or testes.
Johanna Kunz +7 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Timely cancer diagnosis in children and adolescents is important to improving outcomes. We aimed to quantify time to diagnosis and assess variations by patient, demographic and system‐level factors. Procedure We conducted a population‐based study of individuals aged 0–19 years diagnosed with one of 12 cancers from 2010 to 2022 in ...
Callum Mullen +5 more
wiley +1 more source
Crime of Genocide before the Hague International Court [PDF]
Zbornik Radova Pravnog Fakulteta u Splitu, 2016 The I.C.J. has dealt so far with three cases in which its jurisdiction was claimed to be based on Article IX of the 1948 Genocide Convention. In all these cases was involved the Federal Republic of Yugoslavia (FRY).
Vladimir-Đuro Degan
doaj
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo +5 more
wiley +1 more source
Autoprecedente y creación de precedentes en el tribunal supremo
Teoria Jurídica Contemporânea, 2017 RESUMEN: Este trabajo pretende mostrar cómo el mejor o peor cumplimiento de la regla del auto-precedente en un Tribunal Supremo puede repercutr en la efcacia de su función de creación de precedentes para el resto de tribunales. Tras caracterizar el auto-
Marina Gascón
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
A relevância dos precedentes para a eficiência da justiça no Brasil
Revista CNJ, 2019 O artigo examina o papel do Supremo Tribunal Federal na criação (e eventual superação) de precedentes, principalmente a partir de sua regulação pelo atual Código de Processo Civil (Lei nº 13.105/2015).
Oscar Valente Cardoso
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Teoria Jurídica Contemporânea, 2017 RESUMO: O presente artigo analisa a perspectiva crítica do constitucionalismo político, no Reino Unido, em conluio com a consideração dos precedentes enquanto fonte normativa. Dessa forma, busca-se fomentar a análise crítica do precedente constitucional
Lucas Henrique Muniz da Conceição
doaj +1 more source