Results 71 to 80 of about 21,162 (264)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

THREE-DIMENSIONAL NUMERICAL HYDRODYNAMICAL SIMULATION OF LOW/HARD AND HIGH/SOFT STATES IN ACCRETION DISCS OF MICROQUASARS AND QUASARS ON BASE OF UNDEFINED PRECESSION

Odessa Astronomical Publications, 2016
In this study, the models of slaved precession of accretion disc and donors radiationdriven wind were performed using three-dimensional numerical astrophysical methods by the example of microquasar Cyg X-1. As is shown, in the course of precession of the
V. V. Nazarenko, S. V. Nazarenko
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Precessing Ferromagnetic Needle Magnetometer

Physical Review Letters, 2016
A ferromagnetic needle is predicted to precess about the magnetic field axis at a Larmor frequency $Ω$ under conditions where its intrinsic spin dominates over its rotational angular momentum, $N\hbar \gg IΩ$ ($I$ is the moment of inertia of the needle about the precession axis and $N$ is the number of polarized spins in the needle). In this regime the
Jackson Kimball, Derek F, Sushkov, Alexander O, Budker, Dmitry   +2 more
openaire   +6 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

The DRESDYN precession experiment

Comptes Rendus. Physique
The most ambitious project within the DREsden Sodium facility for DYNamo and thermohydraulic studies (DRESDYN) at Helmholtz-Zentrum Dresden-Rossendorf (HZDR) is the set-up of a precession-driven dynamo experiment.
Stefani, Frank, Anders, Sten, Eckert, Sven, Freyer, Nico, Gerbeth, Gunter, Giesecke, André, Gundrum, Thomas, Kaever, Peter, Kumar, Vivaswat, Pizzi, Federico, Räbiger, Dirk, Šimkanin, Ján, Steglich, Christian, Vogt, Tobias, Wagner, Nicole, Wedel, Gerald   +15 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source