Results 51 to 60 of about 119,816 (348)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Pseudo-Newtonian Potentials for Nearly Parabolic Orbits [PDF]

open access: yes, 2012
We describe a pseudo-Newtonian potential which, to within 1% error at all angular momenta, reproduces the precession due to general relativity of particles whose specific orbital energy is small compared to c^2 in the Schwarzschild metric.
Chen   +6 more
core   +2 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Topography-induced flows in a sidewall-modified, rapidly rotating and precessing cylinder

open access: yesEarth and Planetary Physics
The influence of topography on rotating fluids may exceed conventional expectations. Here, we numerically examine viscous incompressible flows induced by sidewall topography, confined within a modified cylinder that rotates rapidly about its central ...
XiuYu Chen   +3 more
doaj   +1 more source

Pulsar state switching, timing noise and free precession [PDF]

open access: yes, 2011
Recent radio pulsar observations have shown that a number of pulsars display interesting long term periodicities in their spin-down rates. At least some of these pulsars also undergo sharp changes in pulse profile.
Jones, D. I.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Resonant relaxation in protoplanetary disks [PDF]

open access: yes, 1998
Resonant relaxation is a novel form of two-body relaxation that arises in nearly Keplerian disks such as protoplanetary disks. Resonant relaxation does not affect the semimajor axes of the particles, but enhances relaxation of particle eccentricities and
Tremaine, Scott
core   +3 more sources

Voltage-controlled spin precession [PDF]

open access: yesPhysical Review B, 2011
A recent experiment reports a non-local spin-signal that shows oscillatory behavior as a function of gate voltage when the contacts are magnetized along the direction of current flow, but not when they are magnetized perpendicular to the current, in agreement with the predictions from a simple theory.
A. N. M. Zainuddin   +4 more
openaire   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Precessing Jet in the High-Redshift Blazar J0017+8135

open access: yesGalaxies, 2016
The prominent flat-spectrum radio quasar J0017+8135 (S5 0014+81) at z = 3.366 is one of the most luminous active galactic nuclei (AGN) known. Its milliarcsecond-scale radio jet structure has been studied with very long baseline interferometry (VLBI ...
Kristóf Rozgonyi, Sándor Frey
doaj   +1 more source

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