Results 51 to 60 of about 21,162 (264)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Comparison of Libration- and Precession-Driven Flows: From Linear Responses to Broadband Dynamics

Fluids
Libration and precession are different body forces that are ubiquitous in many rapidly rotating systems, particularly in geophysical and astrophysical flows.
Ke Wu, Bruno D. Welfert, Juan M. Lopez
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Low-latitude climate variability in the Heinrich frequency band of the Late Cretaceous greenhouse world [PDF]

Climate of the Past, 2014
Deep marine successions of early Campanian age from DSDP (Deep Sea Drilling Project) site 516F drilled at low paleolatitudes in the South Atlantic reveal distinct sub-Milankovitch variability in addition to precession, obliquity and eccentricity-related ...
N. J. de Winter, C. Zeeden, F. J. Hilgen
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Spinning gyroscope in an acoustic black hole: precession effects and observational aspects

European Physical Journal C: Particles and Fields, 2020
The exact precession frequency of a freely-precessing test gyroscope is derived for a $$2+1$$ 2+1 dimensional rotating acoustic black hole analogue spacetime, without making the somewhat unrealistic assumption that the gyroscope is static.
Chandrachur Chakraborty, Parthasarathi Majumdar   +1 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Depth Fluctuations of Mediterranean Outflow Water Along Its Northward Propagation During the Late Pleistocene

Geophysical Research Letters
Mediterranean Outflow Water (MOW) critically influences the Atlantic Meridional Overturning Circulation, yet its northward transport dynamics along the Iberian Margin remain unclear.
Xinyang Chen, Jiawang Wu, Xiaolei Pang, Haowen Dang, Lifeng Zhong, Jimin Yu, Christophe Colin, Zhifei Liu, Gert J. deLange, Stefanie Kaboth‐Bahr, Chuang Xuan, Hisashi Ikeda, Timothy D. Herbert, Huai‐Hsuan May Huang, Carlos A. Alvarez Zarikian, Fátima F. G. Abrantes, David A. Hodell   +16 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source