Mechanism‐Informed Machine Learning Enables Discovery of Oncolytic Peptides for Cancer Immunotherapy
MISPOP integrates ensemble learning with membrane‐active physicochemical priors to identify Dermaseptin‐S9, a natural oncolytic peptide that disrupts tumor membranes, triggers immunogenic cell death, and shows strong antitumor activity. The study illustrates a mechanism‐informed route from peptide sequence data to cancer immunotherapy leads.
Wen Zhang +11 more
wiley +1 more source
Cloud radiative effect dominates variabilities of surface energy budget in the dark Arctic. [PDF]
Tao C, Zhang M, Xie S.
europepmc +1 more source
Tailored Synthesis of Doped Non‐Layered Oxide Nanosheets Using Designed Solid‐State Surfactants
This work reports a solid‐state surfactant templating method that enables precise doping of non‐layered oxide nanosheets. Using ceria and rare‐earth elements as model systems, we established design principles for solid‐state surfactants containing multiple elements.
Kentaro Ito +5 more
wiley +1 more source
ERA5-SH: A global grided scale height dataset for tropospheric parameters based on ERA5 reanalysis. [PDF]
Hao R +5 more
europepmc +1 more source
Optimizing the heterointerface coverage of the conducting Ni2P nanoparticles on the surface of BVO photoanode manipulates the surface Fermi‐level modulation, which significantly enhances photoelectrochemical oxygen evolution reaction. Our multiscale simulations and experimental results reveal that an optimal Ni2P coverage of 9.4% pins the surface Fermi
Phuong Thi Pham +14 more
wiley +1 more source
Gaps and ways forward in atmospheric blocking and extreme weather research. [PDF]
Wang L +9 more
europepmc +1 more source
A multifunctional tantalum incorporation strategy enables simultaneous tuning of carrier concentration, mitigation of grain‐boundary scattering, and enhanced phonon scattering in Mg3(Sb,Bi)2. These synergistic effects markedly improve carrier mobility and suppress lattice thermal conductivity, yielding both high material zT and high module conversion ...
Guangmeng You +9 more
wiley +1 more source
Demonstration of Photonic Integrated Circuit Seed Laser System: Toward Space-Based Water Vapor and Methane Differential Absorption Lidar. [PDF]
Dostart N +12 more
europepmc +1 more source
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu +9 more
wiley +1 more source
Achieving 500-GHz communication over 1.2 km using an astronomical telescope with a quantum-limited superconducting receiver. [PDF]
Miao W +41 more
europepmc +1 more source

