Results 111 to 120 of about 2,435,105 (382)

Precipitation and floodiness [PDF]

Geophysical Research Letters, 2015
AbstractThere are a number of factors that lead to nonlinearity between precipitation anomalies and flood hazard; this nonlinearity is a pertinent issue for applications that use a precipitation forecast as a proxy for imminent flood hazard. We assessed the degree of this nonlinearity for the first time using a recently developed global‐scale ...
Florian Pappenberger, Elisabeth Stephens, Jonny Day, Hannah Cloke   +3 more
openaire   +3 more sources

Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3

FEBS Open Bio, EarlyView.
PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno, Aki Terasaki, Yuiko Imai, Yuri Kimura, Yuna Kojima, Misa Irie, Koya Odaira, Mina Noura, Shuichi Okamoto, Takahiko Yasuda, Shinobu Tsuzuki, Hitoshi Kiyoi, Fumihiko Hayakawa   +12 more
wiley   +1 more source

Using udometric network data to estimate an environmental covariate [PDF]

, 2011
Manyhydrologicalandecologicalstudiesrecognizetheimportanceofcharacterizingthetemporalandspatialvari- ability of precipitation. In this study, geostatistical methodologies were developed in order to estimate a hydro-meteorological factor by (re)building ...
Costa, Marco, Gonçalves, A. Manuela
core   +2 more sources

Frequency of extreme precipitation increases extensively with event rareness under global warming

Scientific Reports, 2019
The intensity of the heaviest extreme precipitation events is known to increase with global warming. How often such events occur in a warmer world is however less well established, and the combined effect of changes in frequency and intensity on the ...
G. Myhre, K. Alterskjær, C. W. Stjern, Ø. Hodnebrog, L. Marelle, B. Samset, J. Sillmann, N. Schaller, E. Fischer, Michael Schulz, A. Stohl   +10 more
semanticscholar   +1 more source

An optimized protocol to detect high‐throughput DNA methylation from custom targeted sequences on 96 samples simultaneously

FEBS Open Bio, EarlyView.
Workflow of a high‐throughput technology for epigenotyping of differentially methylated CpGs in specific regions of the genome. The protocol works with small amounts of DNA extracted from blood or semen. The protocol consists of both enzymatic conversion of unmethylated cytosines and capture by hybridization with a custom panel.
Nathalie Iannuccelli, Sophie Valière, Julien Sarry, Cécile Donnadieu, Julie Demars   +4 more
wiley   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Refining the interpretation of lacustrine carbonate isotope records: Implications of a mineralogy-specific Lake Van case study [PDF]

, 2019
Oxygen and carbon isotope (δ18O and δ13C) data from bulk carbonates are widely applied proxies for temperature, the precipitation/evaporation ratio and productivity in lacustrine palaeohydrology and palaeoclimatology. In case of the terminal and alkaline
Immenhauser, Adrian, Jöns, Niels, Kwiecien, Ola, McCormack, Jeremy, Nehrke, Gernot   +4 more
core   +1 more source

Report on the 2nd MObility for Vesicle research in Europe (MOVE) symposium—2024

FEBS Open Bio, EarlyView.
The 2nd MObility for Vesicle research in Europe (MOVE) Symposium in Belgrade brought over 280 attendees from 28 countries to advance extracellular vesicle (EV) research. Featuring keynotes, presentations, and industry sessions, it covered EV biogenesis, biomarkers, therapies, and manufacturing.
Dorival Mendes Rodrigues‐Junior, Michaela Kocholata, Marilena E. Lekka, Olga Janouskova, Moran Yadid, Maja Kosanovic   +5 more
wiley   +1 more source

Microphysical Characteristics of Melting Layers in North China Revealed by Aircraft and Radar

Remote Sensing
The microphysical processes within the melting layer (ML) of stratiform clouds have been understudied, particularly regarding their intricate properties and behaviors.
Xiangfeng Hu, Shaoyu Hou, Jiefang Yang, Shuwen Zhao, Xiaorui Zhang, Yue Tao, Hongyu Li, Xiaotuo Zhang, Hao Huang   +8 more
doaj   +1 more source

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

FEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová, Tímea Kurdiová, Daria Barkova, Natália Pálešová, Jana Babulicová, Silvia Tyčiaková, Marta Novotová, Mária Balážová, Miroslav Sabo, Václav Pustka, Jozef Ukropec, Barbara Ukropcová   +11 more
wiley   +1 more source