Results 41 to 50 of about 148,512 (255)

Nonlinear responses of ecosystem carbon fluxes to precipitation change in a semiarid grassland

Frontiers in Plant Science
Carbon (C) fluxes in semiarid grasslands subject to precipitation variability play a critical role in the terrestrial C cycle. However, how ecosystem C fluxes respond to variability in precipitation (both decreases and increases precipitation along a ...
Hua Chai, Hua Chai, Jianying Ma, Jinwei Zhang, Junqin Li, Bo Meng, Chengliang Wang, Duofeng Pan, Jie Li, Wei Sun, Xuhui Zhou   +10 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Observational and experimental evidence for the effect of altered precipitation on desert and steppe communities

Global Ecology and Conservation, 2020
Changes in precipitation pattern are likely to affect the community structure and ecosystem function in drylands. Observational and experimental studies can provide insight into how plant community in desert and grassland ecosystems responds to ...
Xiaoan Zuo, Huan Cheng, Shenglong Zhao, Ping Yue, Xinping Liu, Shaokun Wang, Lianxu Liu, Chong Xu, Wentao Luo, J.M.H. Knops, Eduardo Medina-Roldán   +10 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Tropical Pacific Sea Surface Temperature Gradient Biases Shape Present‐Day and Future Precipitation Projections Over Southern Hemisphere Midlatitudes

Geophysical Research Letters
Climate models exhibit significant biases in simulating present‐day tropical Pacific sea surface temperature (SST) patterns, particularly the zonal SST gradient, which may contribute to uncertainties in precipitation projections over mid‐latitude ...
Liping Wang, Kevin M. Grise
doaj   +1 more source

The Response Mechanism of the cbbM Carbon Sequestration Microbial Community in the Alpine Wetlands of Qinghai Lake to Changes in Precipitation

Biology
The dramatic changes in precipitation patterns on the Tibetan Plateau affected the carbon-sequestering microbial communities within wetland ecosystems, which were closely related to the responses and adaptation mechanisms of alpine wetland ecosystems to ...
Lin Li, Xia Wang, Yanli Yang, Siyu Wang, Kelong Chen, Ni Zhang   +5 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

A Novel Reference-Based and Gradient-Guided Deep Learning Model for Daily Precipitation Downscaling

Atmosphere, 2022
The spatial resolution of precipitation predicted by general circulation models is too coarse to meet current research and operational needs. Downscaling is one way to provide finer resolution data at local scales.
Li Xiang, Jie Xiang, Jiping Guan, Fuhan Zhang, Yanling Zhao, Lifeng Zhang   +5 more
doaj   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source