Results 41 to 50 of about 8,491 (265)

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Superior strength–ductility combination in Al alloys via dislocation gradient structure

Materials Research Letters, 2023
The precipitation hardening is widely applied to strengthen Al alloys. Here, we report an alternative way to achieve high-strength Al alloys via forming the dislocation gradient through pre-torsion.
Feng Wang, Yue Li, Xinren Chen, Huan Zhao, Khurram Yaqoob, Yong Du, Zhangwei Wang, Min Song   +7 more
doaj   +1 more source

Superfunctionalities in Nanodispersive Precipitation-Hardened Alloys

Physical Review Letters, 2012
Although nanodispersive precipitation-hardened alloys have been intensively studied over decades as important structural materials, the possibility that these alloys may have superfunctional properties has been completely overlooked. As shown in this Letter, they may have giant low-hysteretic strain responses to external stimuli if the nanosized single-
Wei-Feng, Rao, Armen G, Khachaturyan
openaire   +3 more sources

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Constructing multi-level heterogeneous structures in multi-principal element alloys for superior cryogenic tensile properties

Materials & Design
The multi-level heterogeneous structures, consisting of heterogeneous grain structure, B2 nanoprecipitates, and chemical short-range ordering (CSROs), were designed and fabricated in the (CoNiV)95Al5 multi-principal element alloy.
Luke Xu, Yan Ma, Guohao Qin, Ping Jiang, Xiaolei Wu, Fuping Yuan   +5 more
doaj   +1 more source

Precipitation hardening in gold-cobalt alloys.

The Bulletin of Tokyo Medical and Dental University, 1976
The precipitation hardening in gold-cobalt alloys containing less than 5 wt.%Co was studied by means of resistivity, hardness, X-ray diffraction, and optical microscopic examination. The hardness curves showed two hardness peaks after isothermal ageing below the temperature of 250 or 300 degrees C.
MIYAJIMA, Yutaka, YASUDA, Katsuhiro, KANZAWA, Yasuo   +2 more
openaire   +2 more sources

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Identification and characterization of a gene conferring stress resistance in Escherichia coli and cyanobacteria

FEBS Open Bio, EarlyView.
Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada, Takaaki Tanaka, Manaka Uehara, Keigo Nakano, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Masafumi Yohda   +7 more
wiley   +1 more source

Tailoring size and fraction of coherent L12 nanoprecipitates to achieve strong hardening in medium entropy alloys with heterogeneous grain structures

Journal of Materials Research and Technology
Heterogeneous grain structures with coherent L12 nanoprecipitates were constructed in a medium entropy alloy with chemical composition of Co34.5Cr32Ni27.5Al3Ti3 (at. %).
Guohao Qin, Zihan Zhang, Wei Wang, Xiaolei Wu, Fuping Yuan   +4 more
doaj   +1 more source