Results 41 to 50 of about 585,812 (289)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Maximizing precipitation hardening effect enables ultrahigh strength in a coarse-grained Mg-13Gd forging alloy

Journal of Magnesium and Alloys
In this work, a new strategy for achieving ultrahigh strength in the coarse-grained Mg-Gd binary alloy via utilizing recrystallization texture hardening and maximizing precipitation strengthening has been reported.
Dongdong Zhang, Hucheng Pan, Zhihao Zeng, Weineng Tang, Jingren Li, Hongbo Xie, Rongguang Li, Yuping Ren, Gaowu Qin   +8 more
doaj   +1 more source

Influence of Extrusion Temperature on the Aging Behavior and Mechanical Properties of an AA6060 Aluminum Alloy

Metals, 2018
Processing of AA6060 aluminum alloys for semi-products usually includes hot extrusion with subsequent artificial aging for several hours. Processing below the recrystallization temperature allows for an increased strength at a significantly reduced ...
Nadja Berndt, Philipp Frint, Martin F.-X. Wagner   +2 more
doaj   +1 more source

Effect of thixoforming and precipitation hardening on microstructure and mechanical properties of Al-10.5Si–3Cu-0.2Mg alloy produced by strain induced melt activation process

Journal of Materials Research and Technology, 2021
The effects of the thixoforming and the precipitation hardening heat treatment on the microstructure and mechanical properties of Al-10.5Si–3Cu-0.2Mg alloy produced by the strain-induced melt activation (SIMA) process have been investigated. According to
S.G. Shabestari, M. Abdi, S. Naghdali
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Effect of strain hardening on precipitation kinetics in ATI 718Plus [PDF]

, 2017
ATI 718Plus components are manufactured by forging a wrought billet in stages to obtain the desired geometry and microstructure. Parts are then heat treated to optimized proportions of γ’ and η phases.
Nouveau, Sebastien, Corney, Jonathan, Jonathan Corney, Hassan, Bilal, Jansen, Yann, Bilal Hassan, Sebastien Nouveau, Yann Jansen   +7 more
core   +4 more sources

An intercomparison of global oceanic precipitation climatologies [PDF]

, 2007
Large-scale patterns of precipitation are important for the changes they may effect upon the circulation of the ocean. However, marine precipitation is very hard to quantify accurately.
Srokosz, M.A., Graham D. Quartly, Michael N. Tsimplis, Meric A. Srokosz, Kyte, E.A., Elizabeth A. Kyte, Tsimplis, M.N., Quartly, G.D.   +7 more
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Strength modelling of Al-Cu-Mg Type alloys

, 2006
Age hardening of Al-Cu-Mg type alloys occurs in two stages separated by a constant hardness plateau when the alloys are aged at 110°C to 240?C after solution treatment and quenching.
Yan, Jialin
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source